Basic information Safety Supplier Related

NU6102

Basic information Safety Supplier Related

NU6102 Basic information

Product Name:
NU6102
Synonyms:
  • 6-CYCLOHEXYLMETHOXY-2-(4'-SULFAMOYLANILINO)PURINE
  • CDK1/2 INHIBITOR II
  • NU6102
  • O6-CYCLOHEXYLMETHYL-2-(4-SULFAMOYLANILINO)PURINE
  • 4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]benzenesulfonamide
  • Benzenesulfonamide, 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-
CAS:
444722-95-6
MF:
C18H22N6O3S
MW:
402.47
Mol File:
Mol File
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NU6102 Chemical Properties

Melting point:
152-154℃ (water )
storage temp. 
Store at -20°C
solubility 
DMSO:1.0(Max Conc. mg/mL);2.5(Max Conc. mM)
form 
White to off-white solid.
color 
White to off-white
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NU6102 Usage And Synthesis

Uses

Cyclin-dependent kinases (CDKs) play a key role in regulating cell division by phosphorylating distinct substrates in different phases of the cell cycle. Cell cycle deregulation in many cancers often results from altered CDK activity. Thus, CDKs are potential pharmacological targets for anticancer agents. NU 6102 is a potent inhibitor of Cdk1 and Cdk2 with Ki values of 9 and 6 nM and IC50 values of 9.5 and 5.4 nM, respectively. NU 6102 inhibits Cdk4 activity with an IC50 value of 1.6 μM, suggesting it is most selective for Cdk2. Time-lapse videomicroscopy reveals that 20 μM NU 6102 delays cell entry into mitosis where most cells appear to eventually complete mitotic division but cannot correctly undergo cytokinesis, and hence become binucleated with an abnormal number of centrosomes. In SKUT-1B cancer cells a 24 h exposure to NU 6102 induced G2 arrest, inhibition of target protein phosphorylation, and cytotoxicity with an LC50 value of 2.6 μM.

Uses

NU6102 is a known potent inhibitor of CDK1, CDK2 and CDK7. Cyclin-dependent kinases play a key role in the regulation of cell division which is controlled by the phosphorylation of distinct substrates in different phases of the cell cycle. In any circumstance where the cell cycle is deregulated, cyclin-dependent kinases activities are altered. Since NU6102 is known to exert inhibitory activities against CDKs, it has potential to act as a control in the cell cycle, especially in various cancers. NU6102 is known to be an anticancer agent use to repress the expression of breast cancer cells.

Uses

NU6102 is a known potent inhibitor of CDK1, CDK2 and CDK7. Cyclin-dependent kinases play a key role in the regulation of cell division which is controlled by the phosphorylation of distinct substrates in different phases of the cell cycle. In any circumstance where the cell cycle is deregulated, cyclin-dependent kinases activities are altered. Since NU6102 is known to exert inhibitory activities a gainst CDKs, it has potential to act as a control in the cell cycle, especially in various cancers. NU6102 is known to be an anticancer agent use to repress the expression of breast cancer cells.

storage

+4°C

NU6102Supplier

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Email
tauto@tautobiotech.com
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Email
info@adooq.com
SPIRO PHARMA
Tel
Email
eric_feng1954@126.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com