Basic information Safety Supplier Related

(S)-ROSCOVITINE

Basic information Safety Supplier Related

(S)-ROSCOVITINE Basic information

Product Name:
(S)-ROSCOVITINE
Synonyms:
  • (2S)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
  • Roscovitine, (S)-Isomer - CAS 186692-45-5 - Calbiochem
  • 1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2S)-
CAS:
186692-45-5
MF:
C19H26N6O
MW:
354.45
Mol File:
186692-45-5.mol
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(S)-ROSCOVITINE Chemical Properties

Melting point:
103-106℃
Density 
1.25
storage temp. 
-20C
form 
White solid
color 
White to off-white
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(S)-ROSCOVITINE Usage And Synthesis

Uses

(S)-Roscovitine ((S)-Seliciclib; (S)-CYC202) is a potent and cross the blood-brain barrier CDKs inhibitor. (S)-Roscovitine shows neuroprotective efficacy. (S)-Roscovitine has the potential for the research of stroke[1][2].

in vivo

(S)-Roscovitine (25 mg/kg; i.p.; 15 min before and 1 hr after pMCAo) shows neuroprotective efficacy in an adult mouse model of permanent MCAo (middle cerebral artery occlusion) [2].

Animal Model:20-25 g, P60 male C57 b/6 mice[2]
Dosage:25 mg/kg
Administration:I.p.; at 15 min before and 1 hr after pMCAo
Result:Decreased of the total infarct volume.

IC 50

CDK1: ≤1 μM (IC50); CDK2: ≤1 μM (IC50); CDK5: ≤1 μM (IC50); CDK7: ≤1 μM (IC50); CDK9: ≤1 μM (IC50)

storage

+4°C

References

[1] Le Roy L, et al. Cellular and Molecular Mechanisms of R/S-Roscovitine and CDKs Related Inhibition under Both Focal and Global Cerebral Ischemia: A Focus on Neurovascular Unit and Immune Cells. Cells. 2021 Jan 8;10(1):104. DOI:10.3390/cells10010104
[2] Menn B, et al. Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models. PLoS One. 2010 Aug 12;5(8):e12117. DOI:10.1371/journal.pone.0012117

(S)-ROSCOVITINESupplier

Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Email
klq@cw-bio.com
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Enzo Biochem Inc
Tel
Enzo Biochem Inc. 13797054060
Email
Enzoname@qq.com
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
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