2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE Chemical Properties

Boiling point:

652.3±65.0 °C(Predicted)

Density 

1.30±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

≥20 mg/mL in DMSO; insoluble in H2O; ≥51.1 mg/mL in EtOH with gentle warming

pka

13.95±0.10(Predicted)

form 

White solid

color 

White to off-white

biological source

rabbit

InChI

1S/C20H28N6O3/c1-14(2)26-13-22-17-18(21-12-15-4-6-16(29-3)7-5-15)23-20(24-19(17)26)25(8-10-27)9-11-28/h4-7,13-14,27-28H,8-12H2,1-3H3,(H,21,23,24)

InChIKey

NQVIIUBWMBHLOZ-UHFFFAOYSA-N

SMILES

[n]1(c2nc(nc(c2nc1)NCc3ccc(cc3)OC)N(CCO)CCO)C(C)C

Safety Information

WGK Germany 

WGK 1

Storage Class

11 - Combustible Solids

2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE Usage And Synthesis

Uses

CVT 313 is a potent CDK2 inhibitor.

Biological Activity

Cell permeable: yes', 'Primary Target
Cdk2/A, Cdk2/E', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 0.5 μM for Cdk2/A and Cdk2/E; 4.2 μM for Cdk1/B; 215 μM for Cdk4/D1

IC 50

cdk2/cyclin A: 0.5 μM (IC₅₀); Cdk1/cyclin B: 4.2 μM (IC₅₀); Cdk4/cyclin D1: 215 μM (IC₅₀)

storage

Store at -20°C

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