OLOMOUCINE II Chemical Properties

Boiling point:

618.5±65.0 °C(Predicted)

Density 

1.32

storage temp. 

−20°C

solubility 

chloroform: 50 mg/mL, soluble

form 

powder

pka

9.83±0.30(Predicted)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

OLOMOUCINE II Usage And Synthesis

Definition

ChEBI: 2-[[[2-(1-hydroxybutan-2-ylamino)-9-propan-2-yl-6-purinyl]amino]methyl]phenol is a thiopurine.

General Description

A cell-permeable 2,6,9-trisubstituted purine analog that acts as a potent, reversible, and ATP-competitive inhibitor of Cdk1/B with an IC₅₀ of 20 nM and displays increased potency over purvalanol A (Cat. No. 540500; IC₅₀ = 50 nM), Roscovitine (Cat. No. 557360; IC₅₀ = 450 nM), Bohemine (Cat. No. 203600; IC₅₀ = 1.1 μM) and Olomoucine (Cat. No. 495620; IC₅₀ = 7.0 μM). Further, exerts greater in vitro cytotoxicity in various cancer cell lines (IC₅₀ = 3.0 μM, 5.3 μM, 6.3 μM, 6.3 μM and 11.1 μM for CEM, MCF7, HOS, G631 and K562, respectively).

Biochem/physiol Actions

Cell permeable: yes

OLOMOUCINE II(500735-47-7)Related Product Information

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