Indisulam Chemical Properties

Melting point:

242-243 °C (decomp)(Solv: ethanol (64-17-5); water (7732-18-5))

Boiling point:

668.9±65.0 °C(Predicted)

Density 

1.663±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO : 100 mg/mL (259.17 mM; Need ultrasonic)

form 

powder

pka

8.14±0.30(Predicted)

color 

white to beige

Indisulam Usage And Synthesis

Definition

ChEBI: Indisulam is a chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor and an antineoplastic agent. It is a chloroindole, a sulfonamide and an organochlorine compound.

Biochem/physiol Actions

Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition.

storage

Store at -20°C

Indisulam(165668-41-7)Related Product Information

• Chlorantraniliprole
• Benzenesulfonamide
• Sulfanilamide
• Amlodipine Besylate
• (S)-Amlodipine
• Phenylacetyl chloride
• Diphenyl chlorophosphate
• Hydrochlorothiazide
• 2-CHLOROINDOLE
• 3-CHLORO-1H-INDOL-7-AMINE
• 7-Aminoindole
• Indisulam
• Difluorochloromethane