L-HOMOCYSTEINE Chemical Properties

Melting point:

232°C

Boiling point:

299.7±35.0 °C(Predicted)

Density 

1.149 (estimate)

refractive index 

1.5480 (estimate)

storage temp. 

-20°C

solubility 

Aqueous Acid (Sparingly, Heated, Sonicated), Water (Slightly, Heated)

pka

2.24±0.10(Predicted)

form 

solid

color 

White to Off-White

optical activity

[α]/D 25.5±1.5°, c = 1 in 1 M HCl

Stability:

Air Sensitive, Hygroscopic

InChIKey

FFFHZYDWPBMWHY-VKHMYHEASA-N

CAS DataBase Reference

6027-13-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

29309090

Toxicity

mouse,LD50,intraperitoneal,> 1082mg/kg (1082mg/kg),Yakugaku Zasshi. Journal of Pharmacy. Vol. 94, Pg. 1419, 1974.

L-HOMOCYSTEINE Usage And Synthesis

Chemical Properties

Colourless or nearly colourless solid

Uses

L-homocysteine has been used as a supplement in cell culture media.

Uses

L-Homocysteine is the hydrolysis product of adenosine (A280400), a purine nucleoside. Metabolic fate of L-Homocysteine is converted back to L-Methionine( M260440) via tetrahydrofolate.

Definition

ChEBI: Homocysteine with L configuration.

General Description

L-homocysteine is used to diagnose homocystinuria.

Biochem/physiol Actions

Elevated homocysteine levels in plasma and tissue are associated with brain atrophy in Alzheimer′s disease as well as in healthy eldery subjects. Increased homocysteine is due to deficiencies in vitamin B status, specifically folate, B6 and B12 vitamins, which act as cofactors for enzymes involved in homocysteine metabolism.

Purification Methods

Crystallise L-homocysteine from aqueous EtOH. All operations should be carried out under N2 as the thiol readily oxidizes in air. The acid (3g) is dissolved in freshly boiled H2O (

L-HOMOCYSTEINE(6027-13-0)Related Product Information

• DL,DL-allo-Cystathionine, S-(2-Amino-2-carboxyethyl)homocysteine
• L-ETHIONINE
• DL-ETHIONINE
• FMOC-HOMOCYS(TRT)-OH
• DL-Homocysteine
• D-Homocysteine
• 5μ-Deoxy-S-adenosyl-L-homocysteine, AdoHcy, S-(5μ-Deoxyadenosine-5μ)-L-homocysteine,5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE
• D-ETHIONINE
• N-CHLOROACETYL-DL-HOMOCYSTEINE THIOLACTONE
• DL-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE 99%,Homocysteine thiolactone hydrochloride,DL-Homocysteine thiolactone hydrochloride ,98.5%
• Erdosteine
• Citiolone
• Homocysteine thiolactone
• N-alpha-t-Butyloxycarbonyl-S-trityl-D-homocysteine
• 5-adenyl-L-homocysteine hydrolase
• N-alpha-(9-Fluorenylmethyloxycarbonyl)-S-trityl-D-homocysteine
• S-(1,2-DICHLOROVINYL)-L-HOMOCYSTEINE
• S-Butyl-D-homocysteine,n-Butyl-D-homocysteine