DL-Homocysteinethiolactone hydrochloride Chemical Properties

Melting point:

202 °C (dec.)(lit.)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Fine Crystalline Powder

color 

White

Water Solubility 

740.5 g/L (20 C)

Merck 

14,4734

BRN 

3562103

InChI

InChI=1S/C4H7NOS.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H

InChIKey

ZSEGSUBKDDEALH-UHFFFAOYSA-N

SMILES

C1(N)CCSC1=O.Cl

CAS DataBase Reference

6038-19-3(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

RTECS 

XN1928400

F 

1-8-9

HS Code 

29349990

MSDS

• Language:English Provider:DL-2-Amino-4-mercaptobutyric acid 1,4-thiolactone hydrochloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

DL-Homocysteinethiolactone hydrochloride Usage And Synthesis

Chemical Properties

White Crystalline Powder

Uses

DL-Homocysteine thiolactone hydrochloride is used as an intermediate of erdosteine and citiolone.

General Description

DL-Homocysteine thiolactone hydrochloride (HTL-HCl) is a cyclic amino acid derivative that exhibits root-growth inhibitory activity.

Synthesis

The general procedure for the synthesis of DL-homocysteine thiolactone hydrochloride from DL-homocysteine was as follows: 100 g of DL-methionine was added to a 3-liter cryogenic autoclave pre-cooled to -40°C in a dry ice-acetonitrile solvent mixture, followed by the slow addition of dry ammonia until DL-methionine in the concentrated liquid ammonia was completely dissolved. At a reaction temperature of -35 to -40°C, 60 g of chopped sodium metal was added in batches and the reaction process was followed by liquid chromatography. Upon completion of the reaction, stirring was stopped, the reaction mixture was allowed to stand, and the upper clear night layer was carefully transferred to another three-necked flask. Ammonium chloride was added to quench the reaction and the reaction mixture was allowed to warm up naturally to room temperature until ammonia was completely spilled. The resulting solid was a mixture of DL-homocysteine sodium salt, sodium chloride and ammonium chloride. Treatment by a cation exchange resin to remove sodium ions and subsequent adjustment of the eluate to pH 1 with concentrated hydrochloric acid resulted in 81 g of DL-homocysteine thiolactone hydrochloride in 79% yield.

References

[1] Patent: CN107325073, 2017, A. Location in patent: Paragraph 0018; 0019; 0020; 0021; 0022; 0023; 0024-0034

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