5-Fluoro-2-picolinic acid Chemical Properties

Melting point:

164-166℃

Boiling point:

275.1±20.0 °C(Predicted)

Density 

1.419±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

3.58±0.10(Predicted)

color 

White to Light yellow to Light orange

InChI

InChI=1S/C6H4FNO2/c7-4-1-2-5(6(9)10)8-3-4/h1-3H,(H,9,10)

InChIKey

JTKFIIQGMVKDNZ-UHFFFAOYSA-N

SMILES

C1(C(O)=O)=NC=C(F)C=C1

CAS DataBase Reference

107504-08-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2933399990

5-Fluoro-2-picolinic acid Usage And Synthesis

Synthesis

Potassium phosphate monobasic (1.4 g, 10 mmol) in water (10 mL) was added to a solution of 5-fluoropyridine-2-carbaldehyde (0.50 g, 4.0 mmol, Frontier) in DMSO (10 mL). Sodium chlorite (0.9 g, 0.008 mol) in water (10 mL) was added, and the reaction continued for 1 hour. The mixture was saturated with NaCl, then diluted with EtOAc. The organic layer was further washed with brine, dried over sodium sulfate and concentrated to afford 5-FLUORO-2-PICOLINIC ACID (370 mg, 65%).

5-Fluoro-2-picolinic acid(107504-08-5)Related Product Information

• 3,5-Difluoro-2-pyridinecarboxylic acid
• 2-Fluoronicotinic acid
• 5-AMINO-2-FLUORO-ISONICOTINIC ACID
• 3,5-Difluoropicolinic acid
• 5-FLUORO-6-METHYLPYRIDINE-2-CARBOXYLIC ACID
• 5,6-Difluoropyridine-2-carboxylic acid
• 5,6-Difluoro-4-(trimethylsilyl)pyridine-2-carboxylic acid
• 5-FLUORO-2-PICOLINIC ACID