Basic information Safety Supplier Related

N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid

Basic information Safety Supplier Related

N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid Basic information

Product Name:
N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid
Synonyms:
  • N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid
  • 2-PyridinecarboxaMide, N-(2-aMinoethyl)-5-chloro-, Monohydrochloride
  • Ro 19-6327/001
  • TeMpiuM
  • JMFKTFLARGGXCC-UHFFFAOYSA-N
  • N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride
  • N-(2-Aminoethyl)-5-chlor-2-pyridincarbox
CAS:
103878-83-7
MF:
C8H10ClN3O.HCl
MW:
0
Product Categories:
  • Monoamine Oxidase
Mol File:
103878-83-7.mol
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N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid Chemical Properties

Melting point:
193-195°
storage temp. 
Desiccate at RT
pka
8.9(at 25℃)
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Safety Information

Toxicity
LD50 orally in mice: 1000-2000 mg/kg (Imhof, Kyburz, 1986)
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N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid Usage And Synthesis

Uses

Treatment of Alzheimer’s disease.

brand name

Tempium (Hoffmann-LaRoche).

Biological Activity

Selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC 50 values are 0.03 and > 100 μ M for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC 50 values are 86, 123 and > 500 μ M for noradrenalin, serotonin and dopamine uptake respectively).

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