(R)-N-BOC-4-FLUOROPHENYLGLYCINE Chemical Properties

Melting point:

85.7 °C

Boiling point:

408.4±40.0 °C(Predicted)

Density 

1.2168 (estimate)

storage temp. 

Sealed in dry,Room Temperature

form 

Powder

pka

3.47±0.10(Predicted)

color 

White

CAS DataBase Reference

196707-32-1

Safety Information

Safety Statements 

24/25

HazardClass 

IRRITANT

HS Code 

29224985

MSDS

• Language:English Provider:ACROS

(R)-N-BOC-4-FLUOROPHENYLGLYCINE Usage And Synthesis

Chemical Properties

white powder

Synthesis

Example 59a Single Enantiomeric Isomer; R Configuration NaHCO3 (1.0 g, 11.9 mmol) was added to a stirred aqueous suspension of (R)-4-fluorophenylglycine (1.0 g, 5.9 mmol). after 30 min, a solution of di-tert-butyl dicarbonate (1.5 g, 7.1 mmol) dissolved in tertiary butanol was slowly added dropwise. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the reaction mixture was diluted with water and the pH was subsequently adjusted to 4-5 with 5% aqueous citric acid.The mixture was extracted with dichloromethane (DCM), the organic layer was separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the title compound (R)-2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetic acid (1.6 g). HPLC-MS (Method 17): retention time (Rt) = 2.25 min; mass spectrum (ES+): m/z = 292 [M + Na]+.

References

[1] Patent: US2015/105397, 2015, A1. Location in patent: Paragraph 0385; 0386; 0387; 0388; 0389

(R)-N-BOC-4-FLUOROPHENYLGLYCINE(196707-32-1)Related Product Information

• TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID
• N-BOC-D/L-PHENYLGLYCINOL
• (S)-N-BOC-4-FLUOROPHENYLGLYCINE
• 4-Fluorophenylacetic acid
• 4-Fluorophenylglycine
• (R)-4-Fluorophenylglycine
• BOC-D-PHG-OH
• (R)-N-(tert-Butoxycarbonyl)-2-phenylglycinol
• (S)-1-(4-FLUOROPHENYL)ETHYLAMINE
• FOR-D-PHG-OH
• N-ME-D-PHG-OH
• (S) (-)-ALPHA-PHENETHYLURETHANE
• N-BOC-2-FLUOROPHENYLGLYCINE
• N-BOC- 4-FLUOROPHENYLGLYCINE
• (R)-N-BOC-4-FLUOROPHENYLGLYCINE
• (S)-N-METHYL-1-(4-FLUOROPHENYL)ETHYLAMINE
• (R)-TERT-BUTOXYCARBONYLAMINO-(3,4-DIFLUORO-PHENYL)-ACETIC ACID
• (R)-TERT-BUTOXYCARBONYLAMINO-(2,4-DIFLUORO-PHENYL)-ACETIC ACID