Mozavaptan Hydrochloride Chemical Properties

storage temp. 

2-8°C

solubility 

DMSO: ≥15mg/mL

form 

powder

color 

white to tan

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

Mozavaptan Hydrochloride Usage And Synthesis

Uses

Mozavaptan is a benzazepine derivative that antagonizes the binding of arginine vasopressin (AVP) to vasopressin receptors located in the liver (V1; IC50 = 1.2 μM) and kidney (V2; IC50 = 14 nM). At 10-100 μg/kg, mozavaptan can inhibit the antidiuretic action of AVP, promoting aquaresis when administered intravenously to rats. The therapeutic potential of mozavaptan in ectopic antidiuretic hormone syndrome, heart failure, and other complications related to hyponatremia has been studied.

Definition

ChEBI: Mozavaptane hydrochloride is a member of benzamides.

Biochem/physiol Actions

OPC 31260 is a vasopressin V2 selective antagonist. Arginine vasopressin (AVP) plays an important part in circulatory and water homeostasis. The V2 receptor subtype is important in water retention, cardiac remodeling in congestive heart failure (CHF), and renal hemodynamic alterations, and is considered a target for polysystic kidney disease. OPC-31260 has been shown to inhibit the development of polycystic kidney disease in several animal models.

Mozavaptan Hydrochloride (138470-70-9)Related Product Information

• Trimethylamine hydrochloride
• Betaine hydrochloride
• Pyridine hydrochloride
• Dimethylamine hydrochloride
• Methylamine hydrochloride
• Cysteamine hydrochloride
• Mozavaptan Hydrochloride
• Mozavaptan