5-Aminobenzimidazole Chemical Properties

Melting point:

163-168 °C

Boiling point:

222°C/3.5mmHg(lit.)

Density 

1.367

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

slightly sol. in Methanol

form 

powder to crystal

pka

14.47±0.30(Predicted)

color 

Light yellow to Brown

λmax

300nm(EtOH)(lit.)

InChI

InChI=1S/C7H7N3/c8-5-1-2-6-7(3-5)10-4-9-6/h1-4H,8H2,(H,9,10)

InChIKey

WFRXSXUDWCVSPI-UHFFFAOYSA-N

SMILES

C1NC2=CC(N)=CC=C2N=1

CAS DataBase Reference

934-22-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-36-22

Safety Statements 

26-36/37/39

WGK Germany 

3

RTECS 

DD5785000

HazardClass 

IRRITANT

HS Code 

2933998090

5-Aminobenzimidazole Usage And Synthesis

Uses

5-Aminobenzimidazole is a useful research chemical. It inhibits gastric acid secretion in Shay-rats. Urinary metabolite of cambendazole.

Synthesis

The general procedure for the synthesis of 5-amino benzimidazole from 5-nitrobenzimidazole was as follows: 5-nitrobenzimidazole (10.0 g, 61.3 mmol) was dissolved in methanol (250 mL) and 10% Pd/C catalyst (0.40 g) was added. The hydrogenation reaction was carried out under atmospheric pressure hydrogen atmosphere for 20 hours. Upon completion of the reaction, the catalyst was removed by Celite filtration. The filtrate was concentrated under reduced pressure to give pure 5-aminobenzimidazole (yield not provided).

References

[1] Patent: WO2005/66156, 2005, A1. Location in patent: Page/Page column 33
[2] Patent: EP1437344, 2004, A1. Location in patent: Page 37
[3] Patent: WO2014/162039, 2014, A1. Location in patent: Page/Page column 40
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 2362 - 2370
[5] Recueil des Travaux Chimiques des Pays-Bas, 1948, vol. 67, p. 45,48,51

5-Aminobenzimidazole(934-22-5)Related Product Information

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