ELASTATINAL
ELASTATINAL Basic information
- Product Name:
- ELASTATINAL
- Synonyms:
-
- N-[-N-ALPHA-CARBONYL-CPD-GLN-ALA-AL]-LEU
- elastatinal from microbial source
- L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-L-glutamamide, stereoisomer
- Leu-co-cpd-Gln-Ala-h
- L-Glutamamide, (2S)-2-(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-N-(1S)-1-carboxy-3-methylbutylaminocarbonylglycyl-N1-(1S)-1-methyl-2-oxoethyl-
- (2s)-2-[(4s)-2-amino-1,4,5,6-tetrahydro4-pyrimidinyl]-n-[[[(1s)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-n1-[(1s)-1-methyl-2-oxoethyl-l-glutamamide
- AIDS-006470
- Nα-[2-(2-Amino-1,4,5,6-tetrahydropyrimidin-4-yl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]-L-glycyl]-N1-(1-methyl-2-oxoethyl)-L-glutaminamide
- CAS:
- 51798-45-9
- MF:
- C21H36N8O7
- MW:
- 512.56
- EINECS:
- 257-426-7
- Product Categories:
-
- Enzymes
- Inhibitors
- Miscellaneous Peptides
- Organic Building Blocks
- P to Q
- Peptides and Proteins
- Blood Proteins
- Peptides for Cell Biology
- Plasmin
- Protease Inhibitor Specificity Index
- Protease Inhibitors
- Proteins and Derivatives
- Pepetides
- peptides
- Plasma &
- Aldehydes
- and Substrates
- Bioactive Small Molecules
- Biochemicals and Reagents
- Building Blocks
- C13-C60
- Carbonyl Compounds
- Cell Biology
- Cell Signaling and Neuroscience
- Chemical Synthesis
- Coagulation Proteins and Reagents
- E
- Enzyme Inhibitors
- Enzyme Inhibitors by Enzyme
- Mol File:
- 51798-45-9.mol
ELASTATINAL Chemical Properties
- storage temp.
- -20°C
- solubility
- H2O: 20 mg/mL, clear, yellow
- form
- Yellow solid.
- color
- off-white
- BRN
- 873543
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
MSDS
- Language:English Provider:SigmaAldrich
ELASTATINAL Usage And Synthesis
Description
Elastatinal is a potent inhibitor of pancreatic elastase (Ki = 240 nM) that is produced by various species of Actinomycetes. It more strongly inhibits pancreatic elastase versus the leukocyte-derived enzyme. Elastatinal reduces electrophoretic mobilities of 2A proteinases from poliovirus and human rhinovirus 14 in a dose-dependent manner, indicating substrate recognition by 2A proteinases is similar to that of pancreatic elastases. It can also inhibit elastase-like protease collagenolytic protease from C. maenas digestive glands.
Uses
Elastatinal is an elastase inhibitor.
Biochem/physiol Actions
Potent, irreversible elastase inhibitor. Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes.
References
1) Umezawa et al. (1973), Letter: Elastatinal, a new elastase inhibitor produced by actinomycetes; J. Antibiotics, 26 787 2) Nakajima et al. (1992), Identification of elastase as a secretory protease from cultured rat microglia; J. Neurochem., 58 1401 3) Molla et al. (1993), Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteases by elastase-specific inhibitors; J. Virol., 67 4688 4) Menendez-Arias et al. (1992), Isolation and characterization of alpha 2-macroglobulin-protease complexes from purified mouse mammary tumor virus and culture supernatants from virus-infected cell lines; J. Biol. Chem., 267 11392
ELASTATINALSupplier
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- 821-50328103-801 18930552037
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- 020-39119399 18927568969
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