Polygalacin D
Polygalacin D Basic information
- Product Name:
- Polygalacin D
- Synonyms:
-
- Polygalacin D
- Onjisaponin D
- Olean-12-en-28-oic acid, 3-(β-D-glucopyranosyloxy)-2,16,23-trihydroxy-, O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-α-L-arabinopyranosyl ester, (2β,3β,4β,16α)-
- Polygalacin D2
- (2S,3R,4S,5S)-3-(((2S,3R,4S,5R,6S)-5-(((2S,3R,4S,5R)-4-(((2S,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-3,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-2-yl (4aR,5R,6aS,6bR,8aR,9S,10R,11S,12aR,12bR,14bS)-5,11-dihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-10-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate
- CAS:
- 66663-91-0
- MF:
- C57H92O27
- MW:
- 1209.34
- Mol File:
- 66663-91-0.mol
Polygalacin D Chemical Properties
- Density
- 1.54±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 4°C, protect from light
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 12.76±0.70(Predicted)
- color
- White to off-white
Polygalacin D Usage And Synthesis
Uses
It promotes cognitive function, reduces myocardial damage, and has antitussive and expectorant effects. It is used for content determination/identification/pharmacological experiments, etc.
Chemical Properties
White needle crystal. Soluble in water, ethanol, methanol and other solvents, insoluble in petroleum ether, chloroform, ethyl acetate.
Definition
ChEBI: Polygalacin D is a triterpenoid saponin. It has a role as a metabolite.
Biological Activity
Polygalacin D (PGD) is a bioactive compound with anticancer and antiproliferative properties isolated from Platycodon grandiflorum. It inhibits the expression of the IAP protein family, including survivin, cIAP-1 and cIAP-2 proteins, and blocks the PI3K/Akt pathway by inhibiting GSK3β, Akt phosphorylation and PI3K expression. It induces apoptosis through the PI3K/Akt pathway.
target
NOS | COX | PGE | NO | NF-kB
Polygalacin DSupplier
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Polygalacin D(66663-91-0)Related Product Information
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