Polygalacin D Chemical Properties

Density 

1.54±0.1 g/cm3 (20 ºC 760 Torr)

storage temp. 

4°C, protect from light

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

pka

12.76±0.70(Predicted)

Polygalacin D Usage And Synthesis

Chemical Properties

White needle crystal. Soluble in water, ethanol, methanol and other solvents, insoluble in petroleum ether, chloroform, ethyl acetate.

Definition

ChEBI: Polygalacin D is a triterpenoid saponin. It has a role as a metabolite.

Biological Activity

Polygalacin D (PGD) is a bioactive compound with anticancer and antiproliferative properties isolated from Platycodon grandiflorum. It inhibits the expression of the IAP protein family, including survivin, cIAP-1 and cIAP-2 proteins, and blocks the PI3K/Akt pathway by inhibiting GSK3β, Akt phosphorylation and PI3K expression. It induces apoptosis through the PI3K/Akt pathway.

target

NOS | COX | PGE | NO | NF-kB

Polygalacin D(66663-91-0)Related Product Information

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