GSK 2330672 Chemical Properties

Boiling point:

730.8±60.0 °C(Predicted)

Density 

1.218±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 5 mg/ml; DMSO: 2 mg/ml; PBS (pH 7.2): 0.2 mg/ml

form 

A crystalline solid

pka

3.27±0.10(Predicted)

color 

White to off-white

GSK 2330672 Usage And Synthesis

Description

GSK2330672 is an inhibitor of the apical sodium-dependent bile acid transporter (ASBT; IC₅₀s = 42, 2.1, and 1.9 nM for human, mouse, and rat ASBT, respectively). In vivo, GSK2330672 (0.05 mg/kg) stimulates fecal bile acid secretion, reduces hemoglobin A1c (HbA1c) and plasma glucose levels, and increases total GLP-1 and plasma insulin in Zucker diabetic fatty (ZDF) rats.

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