EPhos Pd G4
EPhos Pd G4 Basic information
- Product Name:
- EPhos Pd G4
- Synonyms:
-
- EPhos Pd G4
- Methanesulfonato{Dicyclohexyl[3-(1-methylethoxy)-2',4',6'-tris(1-methylethyl)-1,1'-biphenyl-2-yl]phosphine}(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) (Ephos Pd G4)
- Dicyclohexyl[3-(1-methylethoxy)-2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine-κP](methanesulfonato-κO)[2′-(methylamino-κN)[1,1′-biphenyl]-2-yl-κC]palladium
- EPhos Catalyst
- Methanesulfonato{Dicyclohexyl[3-(1-methylethoxy)-2',4',6'-tris(1-methylethyl)-1,1'-biphenyl-2-yl]phosphine}(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II)
- dicyclohexyl-[2-isopropoxy-6-(2,4,6-triisopropylphenyl)phenyl]phosphane (N-methyl-2-phenyl-anilino)-methylsulfonyloxy-palladium
- Methanesulfonicacid{bicyclohexyl(3-isopropoxy-2',4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphane}(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II),EphosPdG4
- Dicyclohexyl-[2-propan-2-yloxy-6-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphanium
- CAS:
- 2132978-44-8
- MF:
- C50H70NO4PPdS
- MW:
- 918.57
- Mol File:
- 2132978-44-8.mol
EPhos Pd G4 Chemical Properties
- storage temp.
- 2-8°C, protect from light
- form
- powder or crystals
- Appearance
- Brown to dark brown Solid
EPhos Pd G4 Usage And Synthesis
Uses
Buchwald palladacycle precatalyst with EPhos ligand for Pd-catalyzed C–N cross-coupling between primary amines and aryl halides to form 2-arylaminooxazoles. Catalyst system was reported with NaOPh (CDS001581).
It is a fourth generation (G4) Buchwald precatalyst that is similar to the third generation (G3) precatalysts except that the amino group on the biphenyl backbone is methylated. This modification helps to prevent the limitations of using the third generation precatalysts. It is air, moisture and thermally-stable and shows good solubility in common organic solvents. BrettPhos Pd G4 is highly useful in cross-coupling reactions. Some of its excellent features include lower catalyst loadings, shorter reaction time, and efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.
reaction suitability
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
reaction type: Cross Couplings
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EPhos Pd G4(2132978-44-8)Related Product Information
- Methanesulfonato(2-bis(3,5-di(trifluoromethyl)phenylphosphino)-3,6-dimethoxy-2',6'-bis(dimethylamino)-1,1'-biphenyl )(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II)
- SPhos Palladacycle Gen. 4
- MorDalPhos Pd G4
- XPhos Pd G4
- Xantphos Pd G3
- BrettPhos Pd G3
- t-BuXphos Palladacycle Gen. 4
- Methanesulfonato 2-dicyclohexylphosphino-2-(N,N-dimethylamino)biphenyl(2′-amino-1,1′-biphenyl-2-yl) palladium(II)
- Methanesulfonate(2-Dicyclohexylphosphino-2'-methyl)(2'-Amino-1,1'-Biphenyl-2-Yl)Palladium(II) (Mephos Pd G3)
- QPhos Pd G3
- VPhos Pd G4
- RockPhos Pd G3
- RuPhos Palladacycle Gen. 4
- t-BuBrettPhos Palladacycle Gen. 3
- SPhos Pd G3
- cataCXium A Pd G3
- XantPhos Pd G4
- Methanesulfonato(triphenylphosphine)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) (PPH3 PD G3)