VPhos Pd G4 Chemical Properties

form 

powder or crystals

VPhos Pd G4 Usage And Synthesis

Uses

Buchwald palladacycle precatalyst with new biaryl(dialkyl)phosphine ligand, VPhos, has an improved activity profile for the reductive coupling of non-aromatic heterocyclic alkyl bromides. Its combined use with a surfactant system of octanoic acid/sodium octanoate enables Negishi coupling and access to diverse C(sp³)–C(sp²) cross-coupled products.

It is a fourth-generation (G4) Buchwald precatalysts are similar to the third generation (G3) precatalysts except that the amino group on the biphenyl backbone is methylated. This modification helps to prevent the limitations of using the third generation precatalysts. It is air-, moisture-, and thermally stable and shows good solubility in common organic solvents.

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
reaction type: Cross Couplings

VPhos Pd G4(1848244-57-4)Related Product Information

• Methanesulfonato(2-bis(3,5-di(trifluoromethyl)phenylphosphino)-3,6-dimethoxy-2',6'-bis(dimethylamino)-1,1'-biphenyl )(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II)
• SPhos Palladacycle Gen. 4
• MorDalPhos Pd G4
• XPhos Pd G4
• Xantphos Pd G3
• BrettPhos Pd G3
• t-BuXphos Palladacycle Gen. 4
• Methanesulfonato 2-dicyclohexylphosphino-2-(N,N-dimethylamino)biphenyl(2′-amino-1,1′-biphenyl-2-yl) palladium(II)
• Methanesulfonate(2-Dicyclohexylphosphino-2'-methyl)(2'-Amino-1,1'-Biphenyl-2-Yl)Palladium(II) (Mephos Pd G3)
• QPhos Pd G3
• RockPhos Pd G3
• RuPhos Palladacycle Gen. 4
• t-BuBrettPhos Palladacycle Gen. 3
• SPhos Pd G3
• cataCXium A Pd G3
• EPhos Pd G4
• XantPhos Pd G4
• Methanesulfonato(triphenylphosphine)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) (PPH3 PD G3)