2',4'-Dihydroxy-2-phenylacetophenone Chemical Properties

Melting point:

112-116 °C(lit.)

Boiling point:

225°C/10mmHg(lit.)

Density 

1.278±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

7.74±0.35(Predicted)

color 

White to Light yellow to Light orange

CAS DataBase Reference

3669-41-8(CAS DataBase Reference)

NIST Chemistry Reference

2,4-Dihydroxyphenylbenzyl ketone(3669-41-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

HS Code 

29145000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

2',4'-Dihydroxy-2-phenylacetophenone Usage And Synthesis

Chemical Properties

off-white crystalline powder

Uses

1-(2,4-Dihydroxyphenyl)-2-phenylethanone is used in preparation of substituted pyrazoles, pyrimidines, triazoles and related heterocycles as c-MYC targeting agents for treatment of cancer and other proliferative diseases.

Preparation

Preparation by Friedel–Crafts acylation of resorcinol with phenylacetyl chloride in the presence of aluminium chloride,
? in methylene chloride (85%) ;
? in nitrobenzene at 70–80° for 15 min (<80%), at r.t. for 24 h (63%) or for 2 days (60%);
? in ethyl ether at r.t. for 24 h (43%).

2',4'-Dihydroxy-2-phenylacetophenone(3669-41-8)Related Product Information

• 2-Bromoacetophenone
• 3,4-Dihydroxyacetophenone
• 2,4-Dihydroxyacetophenone
• Benzoyl peroxide
• 4-Nitroacetophenone
• Benzyl benzoate
• Benzyl chloride
• 2-HYDROXYACETOPHENONE
• 3-Nitroacetophenone
• Benzyl alcohol
• Benzyl acetate
• Solvent Red 43
• Acetophenone
• 4'-Methylacetophenone
• 4'-Hydroxyacetophenone
• 6,7,4'-Trihydroxyisoflavone
• Daidzein
• Rotenone