Adrenalone
Adrenalone Basic information
- Product Name:
- Adrenalone
- Synonyms:
-
- ADRENALONE
- AKOS NCG-0050
- 1-(3,4-dihydroxyphenyl)-2-(methylamino)-ethanon
- 3,4-dihydroxy-alpha-methylaminoacetophenone
- 3’,4’-dihydroxy-2-(methylamino)-acetophenon
- 3’,4’-dihydroxy-2-(methylamino)acetophenone
- 4-methylaminoacetocatechol
- 4-methylaminoacetopyrocatechol
- CAS:
- 99-45-6
- MF:
- C9H11NO3
- MW:
- 181.19
- EINECS:
- 202-756-9
- Product Categories:
-
- Pharmaceutical Intermediates
- Mol File:
- 99-45-6.mol
Adrenalone Chemical Properties
- Melting point:
- 235.5°C (rough estimate)
- Boiling point:
- 314.29°C (rough estimate)
- Density
- 1.2375 (rough estimate)
- refractive index
- 1.5270 (estimate)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Aqueous Acid (Slightly)
- form
- Solid
- pka
- 7.32±0.20(Predicted)
- color
- Pale Yellow to Light Yellow
- Stability:
- Hygroscopic
Adrenalone Usage And Synthesis
Originator
Adrenalone ,Yick-Vic Chemicals and Pharmaceuticals (HK) Ltd.
Uses
Adrenergic (ophthalmic).
Uses
Adrenalone is a ketone derivative of Epinephrine (E588585) and a potential dopamine β oxidase inhibitor.
Definition
ChEBI: Adrenalone is an aromatic ketone.
Preparation
Preparation by reaction of excess 33% aqueous methylamine with 3,4-dihydroxy-a-chloroacetophenone.
Manufacturing Process
To a suspension of 1 part ω-chloro-3,4-dihydroxyacetophenone (prerared from chloroacetyl chloride and benzcatechole, see J. Russ. Phys. Chem. Ges., 25, 154) was added dropwise 1 part 60% solution of methylamine. Immediately was formed a residue of the salt of methylamine and ω-chloro-3,4- dihydroxyacetophenone. The dissolution of the salt was carried out by heating of the mixture. Then the salt was converted in crude 3,4-dihydroxy-α- methylaminoacetophenone. The product was dissolved in dilute hydrochloric acid. To this solution was added dropwise aqueous ammonium solution to prepare light yellow crystal of 3,4-dihydroxy-α-methylaminoacetophenone. The base and the hydrochloride of 3,4-dihydroxy-α-methylaminoacetophenone decomposed at temperature near 230°C and 240°C respectively.
Therapeutic Function
Hemostatic, Sympathomimetic, Vasoconstrictor
Adrenalone Preparation Products And Raw materials
Raw materials
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Adrenalone(99-45-6)Related Product Information
- Adrenalone hydrochloride monohydrate, 98+%,ADRENALONE HYDROCHLORIDE 1-HYDRATE,ADRENALONE HCL,ADRENALONE HYDROCHLORIDE
- L-PICEIN
- 3'-DIMETHYLAMINOACETOPHENONE
- Corticotropin
- 3,4-Dihydroxyacetophenone
- 4-Aminoacetophenone
- 2,4-Dihydroxyacetophenone
- 2-Aminoacetophenone
- 2-Aminoecetophenone
- 2'-Methylacetophenone
- Phenylhydrazine
- 3-Aminoacetophenone
- PHENYL VALERATE
- CORTISONE
- 4'-Hydroxyacetophenone
- 3'-(Trifluoromethyl)acetophenone
- L(-)-Epinephrine
- TRIS EDTA ACETATE BUFFER, 10X, DNASE, RNASE AND PROTEASE FREE, PH 8.3, FOR MOLECULAR BIOLOGY