insulin glargine
insulin glargine Basic information
- Product Name:
- insulin glargine
- Synonyms:
-
- insulin glargine
- Insulin Glargine EP/USP
- A21-Gly-B31-Arg-B32-Arg-insulin
- Insulin, glycyl(A21)-arginyl(B31,B32)-
- Lantus
- Solostar
- Solostar [insulin delivery pen]
- Unii-2zm8cx04rz
- CAS:
- 160337-95-1
- MF:
- C267H404N72O78S6
- MW:
- 6062.89026
- Mol File:
- 160337-95-1.mol
insulin glargine Chemical Properties
- storage temp.
- -20°C, Inert atmosphere
- solubility
- Aqueous Acid (Very Slightly)
- form
- Liquid
- color
- White to Off-White
- Sequence
- A-chain: Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Gly; B-chain: Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Thr-Arg-Arg (Disulfide bridge: CysA6-CysA11, CysA7-CysB7, CysA20-CysB19)
- CAS DataBase Reference
- 160337-95-1
insulin glargine Usage And Synthesis
Uses
long-acting basal insulin analogue, helping control the blood sugar level of those with type 1 and type 2 diabetes mellitus. It is an analogue of human insulin made by replacing the asparagine residue at position A21 of the A-chain with glycine and adding
Uses
Insulin Glargine (>90%) is an insulin analogue used in the treatment of adults with type 1 or type 2 diabetes.
brand name
Lantus (Hoechst Marion Roussel).
Biological Activity
Insulin glargine is an approved long-acting insulin analog used for management of Diabetes Type 1 and Type 2. Insulin glargine is a human insulin analog where A-chain asparagine 21 was replaced by glycine and B-chain carboxy terminal was extended by two arginine residues.
in vivo
Insulin glargine (2-12.5 IU/kg; subcutaneous injection; 3-12 months) does not present a carcinogenic risk in rodents[2].
Insulin glargine (450 mg/kg; subcutaneous injection; 6 months) has an improving effect in a mouse model of diabetes[3].
| Animal Model: | Seven-week-old male db/db mice[3] |
| Dosage: | 450 mg/kg |
| Administration: | Subcutaneous injection (s.c.); 6 months |
| Result: | Significantly improved glucose tolerance. Upregulated pancreatic β-cell functional genes, such as INS1, Pdx1, Pax4 and Pax6. |
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