PROTAMINE SULFATE Chemical Properties

storage temp. 

-20°C

solubility 

H₂O: 10 mg/mL

form 

amorphous powder

color 

white

Water Solubility 

It is sparingly soluble in water.

Sensitive 

Hygroscopic

EPA Substance Registry System

Protamines, sulfates (9009-65-8)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

VO9470000

F 

21-10

TSCA 

Yes

HS Code 

35040090

MSDS

• Language:English Provider:SigmaAldrich

PROTAMINE SULFATE Usage And Synthesis

Chemical Properties

White or almost white, hygroscopic powder.

Uses

It is suitable for personal care, cosmetic and pharmaceutical applications. It is used widely to reverse the anticoagulant effects of heparin. It acts as a heparin antagonist. It is also a weak anticoagulant. It may be used for the removal of DNA from protein samples or the purification of DNA binding proteins. Protamine sulfate may also be used as an alternative to polybrene in retroviral mediated gene transfer. Protamine sulfate has antibacterial properties and inhibits pepsin activity. Protamine sulfate and other polycations have been shown to inhibit the classical pathway of complement. It neutralizes the anticoagulant activity of heparin, and inhibits turnover of lipoproteins by lipoprotein lipase. The aggregation of erythrocytes in the presence of protamine sulfate, for application to the prediction of MN phenotypes, has been investigated.

Uses

Antidote (to heparin).

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