PROTAMINE SULFATE
PROTAMINE SULFATE Basic information
- Product Name:
- PROTAMINE SULFATE
- Synonyms:
-
- Protamin sulfate
- ProtamineSulphateExSalmonRoe
- PROTAMINE SULFATE SALT
- Protamine sulfate, Salmine sulfate from salmon sperm
- Protamine sulfate 1g [9009-65-8]
- Ccris 8521
- Protamina solfato
- Protamina solfato [dcit]
- CAS:
- 9009-65-8
- MF:
- H2O4S
- MW:
- 0
- EINECS:
- 618-450-7
- Mol File:
- Mol File
PROTAMINE SULFATE Chemical Properties
- storage temp.
- -20°C
- solubility
- H2O: 10 mg/mL
- form
- amorphous powder
- color
- white
- Water Solubility
- It is sparingly soluble in water.
- Sensitive
- Hygroscopic
- EPA Substance Registry System
- Protamines, sulfates (9009-65-8)
MSDS
- Language:English Provider:SigmaAldrich
PROTAMINE SULFATE Usage And Synthesis
Chemical Properties
White or almost white, hygroscopic powder.
Uses
It is suitable for personal care, cosmetic and pharmaceutical applications. It is used widely to reverse the anticoagulant effects of heparin. It acts as a heparin antagonist. It is also a weak anticoagulant. It may be used for the removal of DNA from protein samples or the purification of DNA binding proteins. Protamine sulfate may also be used as an alternative to polybrene in retroviral mediated gene transfer. Protamine sulfate has antibacterial properties and inhibits pepsin activity. Protamine sulfate and other polycations have been shown to inhibit the classical pathway of complement. It neutralizes the anticoagulant activity of heparin, and inhibits turnover of lipoproteins by lipoprotein lipase. The aggregation of erythrocytes in the presence of protamine sulfate, for application to the prediction of MN phenotypes, has been investigated.
Uses
Antidote (to heparin).
in vivo
Protamine sulfate can be used in animal modeling to create cystitis models[5].
Administration: 10 mg/mL irrigation in the urinary bladder ? once
(2) 5 days later, the experimental animals were put to death under anesthesia, and the bladder was removed for observation.
Molecular changes: The levels of biomarkers IL-6, TNF-α and NF-κB in bladder tissues were detected.
Histological analysis: Hematoxylin and eosin staining were used to detect the number of mast cells in the bladder of rats.
PROTAMINE SULFATE Preparation Products And Raw materials
Raw materials
PROTAMINE SULFATESupplier
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PROTAMINE SULFATE(9009-65-8)Related Product Information
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- insulin glargine
- Palmitoyl tetrapeptide-7
- SALMINE,SALMINE SULFATE,salmine,sulfate(1:1
- Isovanillin
- Vanillin
- SALMINE SULFATE FROM SALMON SPERM