TRIETHYL 4-PHOSPHONOCROTONATE Chemical Properties

Boiling point:

135 °C0.4 mm Hg(lit.)

Density 

1.128 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.455(lit.)

Flash point:

>230 °F

form 

Liquid

color 

Clear light yellow

CAS DataBase Reference

10236-14-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-24/25

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29319090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

TRIETHYL 4-PHOSPHONOCROTONATE Usage And Synthesis

Chemical Properties

CLEAR LIGHT YELLOW LIQUID

Uses

Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.

Uses

Reactant for:

• Iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase
• Stereoselective preparation of C1-C19 fragment of macrolide antibiotic aplyronine A using diastereoselective Nozaki-Hiyama-Kishi coupling reactions
• Orally bioavailable GPR40 agonist synthesis
• Synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2
• Preaparation of mGlu4R agonists
• Dearomatizing cyclization of nicotinyl-substituted esters and ketones

TRIETHYL 4-PHOSPHONOCROTONATE(10236-14-3)Related Product Information

• TRIETHYL 4-PHOSPHONOBUTYRATE
• TRIETHYL 3-PHOSPHONOPROPIONATE
• Dimethyl methylphosphonate
• DIMETHYL ETHYLPHOSPHONATE
• DIETHYL ALLYLPHOSPHONATE
• Methyldiethoxyphosphine
• DIMETHYL ALLYLPHOSPHONATE
• ETHYL METHYLPHOSPHONIC ACID
• METHYLPHOSPHONIC ACID
• ETHYLPHOSPHONIC ACID
• TRIETHYL 4-PHOSPHONOCROTONATE
• DIMETHYL ETHYLPHOSPHONITE
• DIETHYL ETHYLPHOSPHONATE
• Diethyl methylphosphonate
• TRIMETHYL 4-PHOSPHONOCROTONATE
• TRIETHYL 3-METHYL-4-PHOSPHONOCROTONATE
• ETHYL HYDROGEN ETHYLPHOSPHONATE
• ALLYLPHOSPHONIC ACID