2-Hydroxy-2-methylbutyric acid Chemical Properties

Melting point:

73-75 °C (lit.)

Boiling point:

109 °C / 9mmHg

Density 

1.144±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in DMSO

form 

powder to crystal

pka

pK1:3.991 (18°C)

color 

White to Almost white

Water Solubility 

within almost transparency

CAS DataBase Reference

3739-30-8(CAS DataBase Reference)

NIST Chemistry Reference

2-Hydroxy-2-methylbutyric acid(3739-30-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

HS Code 

2918199890

MSDS

• Language:English Provider:SigmaAldrich

2-Hydroxy-2-methylbutyric acid Usage And Synthesis

Uses

2-Hydroxy-2-methylbutyric acid can be used as:

• A complexing agent in a new electrolytic system, applicable in the isotachophoretic lanthanide separation.
• An aldehyde surrogate to prepare pyrrolo[1,2-a]quinoxaline derivatives by reacting with 2-(1H-pyrrol-1-yl)aniline.
• A starting material to synthesize Cr(V) reagent named sodium bis(2-hydroxy-2-methylbutyrato)oxochromate(V) (Aldrich cat. no. ALD00006) applicable in the total synthesis of (?)-taxuyunnanine D.

Definition

ChEBI: A branched-chain fatty acid that is 2-methylbutyric acid substituted at C-2 by a hydroxy group.

Purification Methods

Crystallise the acid from *benzene, and sublime it at 90o. [Beilstein 3 H 324.] IRRITANT.

2-Hydroxy-2-methylbutyric acid (3739-30-8)Related Product Information

• Indole-3-butyric acid
• 4-Aminobutyric acid
• CHLOROPHOSPHONAZO III
• Ethyl 2-(Chlorosulfonyl)acetate
• Hydrocortisone-17-butyrate
• 2-Methyl butyric acid
• Folic acid
• 2,2-Bis(hydroxymethyl)butyric acid
• FERRIC CITRATE
• Ammonium ferric citrate
• Trolox
• Triethyl citrate
• AGARIC ACID
• Citric acid
• alpha-Cyclopentylmandelic acid
• SODIUM DIHYDROGEN CITRATE
• 2-ETHYL-2-HYDROXYBUTYRIC ACID
• Quinic acid