2,5-Dichlorobenzaldehyde Chemical Properties

Melting point:

54-57 °C (lit.)

Boiling point:

231-233 °C

Density 

1.3456 (rough estimate)

refractive index 

1.5756 (estimate)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

Crystalline Powder

color 

White to off-white

Sensitive 

Air Sensitive

BRN 

1635476

InChI

InChI=1S/C7H4Cl2O/c8-6-1-2-7(9)5(3-6)4-10/h1-4H

InChIKey

BUXHYMZMVMNDMG-UHFFFAOYSA-N

SMILES

C(=O)C1=CC(Cl)=CC=C1Cl

CAS DataBase Reference

6361-23-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

RIDADR 

1759

WGK Germany 

3

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

III

HS Code 

29130000

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,5-Dichlorobenzaldehyde Usage And Synthesis

Chemical Properties

white to off-white crystalline powder

Synthesis Reference(s)

Journal of Medicinal Chemistry, 23, p. 506, 1980 DOI: 10.1021/jm00179a007

Synthesis

General procedure for the synthesis of 2,5-dichlorobenzaldehyde from 2,5-dichlorobenzenemethanol: 2,5-dichlorobenzenemethanol (1 mmol), water (1 mL), and CoFe2O4 magnetic nanoparticles (11.8 mg, 5 mol%) were added to a round bottom flask. The reaction mixture was stirred for 2 min and then Oxone (0.6 mmol) was added in three batches. The reaction mixture was stirred at room temperature for the indicated time (refer to Table 5). The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ethyl acetate-cyclohexane, 2:10, v/v). After completion of the reaction, the product was extracted with dichloromethane. The solvent was removed by distillation under reduced pressure to obtain the crude product. The crude product was purified using silica gel column chromatography to obtain pure 2,5-dichlorobenzaldehyde. Finally, the aliphatic by-products in dichloromethane were dried with anhydrous magnesium sulfate and analyzed by gas chromatography-flame ionization detector (GC-FID).

References

[1] Collection of Czechoslovak Chemical Communications, 1982, vol. 47, # 11, p. 3077 - 3093
[2] Applied Organometallic Chemistry, 2018, vol. 32, # 1,
[3] Bulletin of the Korean Chemical Society, 2014, vol. 35, # 7, p. 2029 - 2032
[4] Patent: EP1661877, 2006, A1. Location in patent: Page/Page column 18
[5] Journal of Medicinal Chemistry, 1980, vol. 23, # 5, p. 506 - 511

2,5-Dichlorobenzaldehyde(6361-23-5)Related Product Information

• 4-Hydroxybenzaldehyde
• p-Anisaldehyde
• 3-(METHOXYMETHOXY)BENZALDEHYDE
• 4-Dimethylaminobenzaldehyde
• 2,6-Dichlorobenzaldehyde
• Salicylaldehyde
• 3-(Trifluoromethyl)benzaldehyde
• 2,3-Dichlorobenzaldehyde,99%,2,3-DICHLOROBENZALDEHYDE
• 2-Nitrobenzaldehyde
• Benzaldehyde
• 2,4-Dichlorobenzaldehyde
• 2,5-DICHLOROBENZHYDRAZIDE
• 2',5'-Dichloroacetophenone
• Tetrachlorophthalic anhydride
• 2,3,6-TRICHLOROBENZALDEHYDE
• 2,5-Dichlorobenzoic acid
• 2,5-Dichloro-3-nitrobenzoic acid
• 3,5-Dichlorobenzaldehyde