Azido-PEG8-hydrazide Chemical Properties

solubility 

Soluble in Water

form 

Solid

color 

White to off-white

Azido-PEG8-hydrazide Usage And Synthesis

Description

Azido-PEG8-hydrazide HCl salt is a wter soluble PEG linker containing an azide group and a hydrazide moiety. The hydrophilic PEG spacer increases solubility of a compound in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydrazide group can react with an aldehyde to form a semi-permanent hydrozone bond.

Uses

Azido-PEG8-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG8-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azido-PEG8-hydrazide(2353410-11-2)Related Product Information

• Azido-PEG8-NHBoc
• Azido-PEG8-azide
• O-(2-AMINOETHYL)-O-(2-AZIDOETHYL)HEPTAETHYLENE GLYCOL
• Azido-PEG8-t-butyl ester
• alpha-Azido-omega-hydroxy octa(ethylene glycol)
• Azido-PEG8-NHS ester
• Azido-PEG8-Br
• N3-PEG8-Tos
• N3-PEG8-CH2CH2COOH