Azido-PEG8-t-butyl ester Chemical Properties

storage temp. 

Store at Room Tem.

solubility 

Soluble in Water, DMSO, DCM, DMF

form 

Liquid

color 

Light yellow to yellow

Azido-PEG8-t-butyl ester Usage And Synthesis

Description

Azido-PEG8-t-butyl ester is a click chemistry compound conpprising an azide group and a t-butyl ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

Uses

Azido-PEG8-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1]. Azido-PEG8-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs; Alkyl/ether

References

[1] Garofalo, Antonio, et al. Efficient synthesis of small-sized phosphonated dendrons: potential organic coatings of iron oxide nanoparticles. New Journal of Chemistry (2014), 38(11), 5226-5239.

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