Azide-PEG5-t-butyl ester Chemical Properties

storage temp. 

Storage temp. 2-8°C

form 

Liquid

color 

Colorless to light yellow

Azide-PEG5-t-butyl ester Usage And Synthesis

Description

Azide-PEG5-t-butyl ester is a click reagent containing an azide with azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

Uses

Azide-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG5-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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