Azido-peg4-pfp ester Chemical Properties

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in DMSO, DCM, DMF

form 

Liquid

color 

Colorless to light yellow

Safety Information

HS Code 

2942000090

Azido-peg4-pfp ester Usage And Synthesis

Description

Azido-PEG4-PFP ester is a click reagent containing an azide group and a PFP moiety. The azide group enables Click Chemistry. The PFP ester is can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules, comparing with NHS ester, PFP ester is more stable.. The hydrophilic PEG spacer adds to the water solubility of this reagent.

Uses

N3-PEG4-C2-Pfp ester is a nonclaevable 4-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG4-C2-Pfp ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Non-cleavable Linker

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