2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL Chemical Properties

Flash point:

-33℃

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

Oil

color 

Colourless to Light Yellow

Appearance

colorless liquid

BRN 

4418543

InChI

InChI=1S/C6H13N3O3/c7-9-8-1-3-11-5-6-12-4-2-10/h10H,1-6H2

InChIKey

PMNIHDBMMDOUPD-UHFFFAOYSA-N

SMILES

C(O)COCCOCCN=[N+]=[N-]

Safety Information

Hazard Codes 

F,Xi

Risk Statements 

11-38

Safety Statements 

16

RIDADR 

UN 2398 3 / PGII

WGK Germany 

3

HS Code 

2929900090

2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL Usage And Synthesis

Description

Azido-PEG3-alcohol is a click chemistry PEG linker containing an azide group and a terminal hydroxyl group. The azide group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Chemical Properties

Yellowish Liquid

Uses

Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Azido-PEG3-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

reaction suitability

reaction type: click chemistry
reagent type: linker

IC 50

PEGs

References

[1] Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. DOI:10.1016/j.bmc.2019.115228

2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL(86520-52-7)Related Product Information

• N3-PEG4-tBu
• Azido-PEG12-NHS ester
• Azido-PEG8-NHS ester
• Azido-PEG2-acid
• Azide-PEG5-t-butyl ester
• Azido-PEG2-t-butyl ester
• Azido-PEG5-NHS ester
• Azido-dPEG4-acid
• N3-PEG3-tBu
• Azido-PEG12-t-butyl ester
• N3-PEG6-tBu
• 1-AZIDO-3,6,9-TRIOXAUNDECANE-11-OL
• 1-Azidohexaethylene Glycol
• 3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine
• MPEG8-N3
• Azido-PEG6
• AMINO-PEG12-T-BUTYL ESTER
• 1-AMINO-3,6,9-TRIOXAUNDECANYL-11-OL