N-Boc-4-piperidinemethanol
N-Boc-4-piperidinemethanol Basic information
- Product Name:
- N-Boc-4-piperidinemethanol
- Synonyms:
-
- 1-N-BOC-4-HYDROXYMETHYL-PIPERIDINE
- 1-(TERT-BUTOXYCARBONYL)-4-(HYDROXYMETHYL)PIPERIDINE
- 1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINEMETHANOL
- TERT-BUTYL 4-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
- TERT-BUTYL 4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE
- N-T-BUTOXYCARBONYL-HEXAHYDROISONICOTINOL
- N-T-BUTOXYCARBONYL-4-HYDROXYMETHYL-PIPERIDINE
- N-T-BUTOXYCARBONYL-4-PIPECOLINOL
- CAS:
- 123855-51-6
- MF:
- C11H21NO3
- MW:
- 215.29
- EINECS:
- 628-428-9
- Product Categories:
-
- Piperidine Series
- Heterocycles
- Amines
- blocks
- Piperidine
- Piperazine
- 123855-51-6
- Mol File:
- 123855-51-6.mol
N-Boc-4-piperidinemethanol Chemical Properties
- Melting point:
- 78-82 °C (lit.)
- Boiling point:
- 308.0±15.0 °C(Predicted)
- Density
- 1.059±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- pka
- 14.94±0.10(Predicted)
- form
- Powder
- color
- White to brown
- InChI
- InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-6-4-9(8-13)5-7-12/h9,13H,4-8H2,1-3H3
- InChIKey
- CTEDVGRUGMPBHE-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(CO)CC1
- CAS DataBase Reference
- 123855-51-6(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
N-Boc-4-piperidinemethanol Usage And Synthesis
Chemical Properties
White to light brown solid
Uses
N-Boc-4-piperidinemethanol is an important piperidine derivative, which can be used in organic synthesis and pharmaceutical intermediates, It may be used to synthesize:
methyl 5-methoxy-4-(1-methylpiperidin-4-ylmethoxy)-2-nitrobenzoate
N-Boc-4-piperidinecarboxaldehyde
[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl methanesulfonate
Involved in the synthesis of bradycardic agents.
Application
N-Boc-4-piperidinemethanol is a curcumin analogue that binds to the epidermal growth factor receptor (EGFR) and prevents the binding of ligands. In vitro studies have shown that it can inhibit tumor growth and induce apoptosis in cancer cells. The drug is also capable of inhibiting the proliferation of normal cells, which may be due to its ability to recruit EGFR from outside the cell membrane. This process triggers signaling events that lead to cell death.
General Description
N-Boc-4-piperidinemethanol contains a tert-butyloxycarbonyl (t-BOC)-protecting group. It can be synthesized from 4-piperidinemethanol via reaction with di-tert-butyldicarbonate.
N-Boc-4-piperidinemethanolSupplier
- Tel
- 0531-82375892 15562613975
- 3416953599@qq.com
- Tel
- 21-61026752 13918007836
- sales@hoborchem.com
- Tel
- 025-66099280 17798518460
- cfzhang@aikonchem.com
- Tel
- 0513-0513-68015397 18862996710
- sales12@btcpharm.com
- Tel
- 0513-82104991 18068193575
- sales11@btcpharm.com
N-Boc-4-piperidinemethanol(123855-51-6)Related Product Information
- N-Boc-Piperidine-4-carboxylic acid methyl ester
- DROPERIDOL
- N-(tert-Butoxycarbonyl)-4-piperidone
- Haloperidol
- 2,2,6,6-Tetramethyl-4-piperidinol
- PHENCYCLIDINE-D5 HYDROCHLORIDE
- tert-Butyl acetate
- tert-Butyl peroxyacetate
- 4-Piperidinemethanol
- tert-Butanol
- 1-Boc-2-piperidinemethanol,1-N-Boc-2-piperidinemethanol,1-TERT-BUTOXYCARBONYL-2-PIPERIDINEMETHANOL, N-BOC-2-PIPERIDINEMETHANOL
- 1-TERT-BUTOXYCARBONYL-3-PIPERIDINEMETHANOL, N-BOC-3-PIPERIDINEMETHANOL,1-Boc-3-piperidinemethanol
- 1-Boc-4-(2-hydroxyethyl)piperidine
- N-BOC-4-Hydroxypiperidine
- tert-Butyl 4-methylenepiperidine-1-carboxylate
- 1-Boc-4-cyanopiperidine
- N-Boc-(2R,3R,4S)-dolaproine
- TERT-BUTYL N-(2-HYDROXYETHYL)CARBAMATE