Polygalacic acid
Polygalacic acid Basic information
- Product Name:
- Polygalacic acid
- Synonyms:
-
- Polygalacic acid
- Polygalacic
- (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
- Olean-12-en-28-oicacid, 2,3,16,23-tetrahydroxy-, (2β,3β,4,16)-
- Virgaureagenin G
- (4R)-2β,3β,16α,23-Tetrahydroxyolean-12-en-28-oic acid
- Polygalacic acid or (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
- Polygalacic acid (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
- CAS:
- 22338-71-2
- MF:
- C30H48O6
- MW:
- 504.7
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 22338-71-2.mol
Polygalacic acid Chemical Properties
- Melting point:
- 300-305 °C (sublm)
- Boiling point:
- 638.1±55.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 4.41±0.70(Predicted)
- color
- White to off-white
Polygalacic acid Usage And Synthesis
Uses
Polygalacic acid can be used to calm the nerves, eliminate phlegm, reduce swelling, etc. It is mostly used clinically to treat bronchitis, induce labor, and induce labor.
Biological Activity
Polygalacic acid is a triterpenoid tetrahydroxy acid isolated from Polygala paenea L.. It (0-100μM; 24h) can significantly reduce the mRNA expression of MMP-3, MMP-9, MMP-13 and COX-2, and the expression of these factors can be significantly increased by IL-1β in a dose-dependent manner .
in vitro
Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a In a dose-dependent manner. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid.
RT-PCR
| Cell Line: | Chondrocyte cells |
| Concentration: | 50 μM; 100 μM |
| Incubation Time: | 24 hours |
| Result: | Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression. |
Western Blot Analysis
| Cell Line: | Chondrocyte cells | Concentration: | 50 μM; 100 μM |
| Incubation Time : | 6 hours |
| Result: | Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes. |
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