Herbacetin
Herbacetin Basic information
- Product Name:
- Herbacetin
- Synonyms:
-
- 3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-1-benzopyran-4-one
- 3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one
- 3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
- Herbacetin, 98%, from Rhodiola rosea L.
- 3,5,7,8,4'-Pentahydroxyflavone/3,5,7,3',4',8-Hexahydroxyflavone - Herbacetin/Gossypetin mixture
- HERBACETIN(P)(PLEASE CALL)
- 3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
- Isoarticulatidin
- CAS:
- 527-95-7
- MF:
- C15H10O7
- MW:
- 302.24
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- Penta-substituted Flavones
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 527-95-7.mol
Herbacetin Chemical Properties
- Melting point:
- 284℃
- Boiling point:
- 618.7±55.0 °C(Predicted)
- Density
- 1.799
- solubility
- DMF:30.0(Max Conc. mg/mL);99.26(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);99.26(Max Conc. mM)
DMSO:PBS(pH 7.2) (1:4):1.0(Max Conc. mg/mL);3.31(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);6.62(Max Conc. mM) - form
- A crystalline solid
- pka
- 6.49±0.40(Predicted)
- LogP
- 1.140 (est)
Herbacetin Usage And Synthesis
Chemical Properties
Soluble in methanol, ethanol, DMSO and other organic solvents, derived from the aerial part of Equisetum, Rhodiola rosea.
Uses
Herbacetin is a flavonol compound, and a natural inhibitor of E.coli β-glucuronidase. Herbacetin inhibits inducible nitric oxide synthase via JNK and nuclear factor-κB in LPS-stimulated RAW264.7 cells. Molecular docking study of flavonoid compounds as an inhibitor of β-ketoacyl acyl carrier proteinsynthase II of Pseudomonas aeruginosa.
Definition
ChEBI: Herbacetin is a pentahydroxyflavone that is kaempferol substituted by a hydroxy group at position 8. It is a natural flavonoid from flaxseed which exerts antioxidant, anti-inflammatory and anticancer activities. It has a role as an EC 4.1.1.17 (ornithine decarboxylase) inhibitor, an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor, a plant metabolite, an antilipemic drug, an anti-inflammatory agent and an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor. It is a pentahydroxyflavone and a 7-hydroxyflavonol. It is functionally related to a kaempferol.
Biological Activity
Herbacetin is a natural flavonoid in flaxseed with a variety of pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects. Gluprotamine is an allosteric inhibitor of Ornithine decarboxylase (ODC), which directly binds to Asp44, Asp243 and Glu384 on ODC.
in vivo
Herbacetin (orally administration; 20mg/kg) significantly reduces the body weight, plasma glucose, plasma insulin, and HOMA-IR activity in obesity associated insulin resistant mice (OIR). (Herbacetin dissolves in 0.5% DMSO) .Herbacetin (intraperitoneal injection; 0.4, 2, 10 or 20 mg/kg; BW) decreases the number and size of polyps in APCM in+ mice with no overt toxicity.
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Herbacetin(527-95-7)Related Product Information
- Quercetin-7-O-β-D-glucopyranoside
- Naringenin 7-O-β-D-Glucuronide (Mixture of Diastereomers)
- ROSARIN
- Herbacetin 7-rhamnoside
- Leucoside
- 7,8-Dihydroxycoumarin
- Kaempferol
- Phloretin
- 3,7,3',4'-TETRAMETHYLGOSSYPETIN
- GOSSYPIN
- 5,3',4'-trihydroxy-3,6,7,8-tetramethoxyflavone
- GOSSYPETIN
- HERBACETIN-3,8-DIGLUCOPYRANOSIDE
- Herbacetin
- 3,3',4',5,6,7,8-heptamethoxyflavone
- HERBACETIN 8-GLUCOSIDE-3-SOPHORISIDE
- HEPTAMETHOXYFLAVONE
- HERBACETIN-7-O-GLUCORHAMNOSIDE