11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Basic information
- Product Name:
- 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
- Synonyms:
-
- 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
- Dopamine serotonin antagonist-1
- Dechloroclozapine
- 5H-Dibenzo[b,e][1,4]diazepine, 11-(4-methyl-1-piperazinyl)-
- 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepineQ: What is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine Q: What is the CAS Number of 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
- inhibit,Inhibitor,Muscarinic acetylcholine receptor,hM4Di,Deschloroclozapine,hM3Dq,muscarinic-based,mAChR,DREADDs
- CAS:
- 1977-07-7
- MF:
- C18H20N4
- MW:
- 292.38
- Mol File:
- 1977-07-7.mol
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11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Chemical Properties
- Boiling point:
- 457.5±55.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO : ≥ 83.3 mg/mL (284.90 mM)
- pka
- 7.82±0.20(Predicted)
- form
- solid
- color
- Yellow
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11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Usage And Synthesis
Biological Activity
Deschloroclozapine is a potent, high-affinity, selective, metabolically stable agonist of muscarinic-based DREADDs.
in vitro
Deschloroclozapine has greater potencies for DREADDs than previous agonists in vitro. Deschloroclozapine is a potent agonist for hM 3 Dq with an EC 50 =0.13 nM. Deschloroclozapine is also a potent agonist for hM 4 Di with an EC 50 =0.081 nM.
Deschloroclozapine is a potent and selective agonist for hM 3 Dq and hM 4 Di, it does not display significant agonistic activity for any of the 318 tests wild-type GPCRs at <10 nM.
b>
target
Ki: 6.3 nM (hM 3 Dq), 4.2 nM (hM 4 Di)
storage
Room temperature
11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepineSupplier
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