1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE Chemical Properties

Melting point:

77-79 °C(lit.)

Boiling point:

173-175 °C

Flash point:

100 °C

storage temp. 

2-8°C

solubility 

Slightly soluble in water, very soluble in ethanol (96 per cent), soluble in glycerol (85 per cent).

form 

Crystalline Powder, Crystals and/or Chunks

color 

White to almost white

Water Solubility 

Soluble in ethanol, ether, chloroform, and glycerol. Insoluble in water.

Merck 

14,2129

BRN 

878167

Stability:

Stable. Generates toxic fumes on combustion. Incompatible with strong oxidizing agents.

LogP

2.074 (est)

CAS DataBase Reference

6001-64-5

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36/37/39

WGK Germany 

3

RTECS 

UC0175000

TSCA 

Yes

HS Code 

29055900

MSDS

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1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE Usage And Synthesis

Chemical Properties

white crystalline solid

Uses

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate in combination with dimethyl sulfone, can serve as an appropriate solvent for the freeze drying of certain parenteral organic drugs, which have an increase in many factors such as stability, dissolution rate, dosing accuracy and sterility.

Uses

Pharmaceutic aid (antimicrobial agent).

Uses

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate converts benzisoxazole to α-aryloxyisobutyric acid. It forms eutectic with dimethyl sulfone, which is the most suitable media for freeze-drying due to its high solubilizing ability and a good rate of solvent removal.

brand name

Chloretone (Parke-Davis).

General Description

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) converts benzisoxazole to α-aryloxyisobutyric acid. 1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) forms eutectic with dimethyl sulfone, which is the most suitable media for freeze-drying due to its high solubilizing ability and a good rate of solvent removal.

Biochem/physiol Actions

Chlorobutanol or 1,1,1-Trichloro-2-methyl-2-propanol is a opthalmic preservative and sedative hypnotic that possess antibacterial and antifungal properties. It also decreases the conduction velocity and induces conduction failure and automaticity within isolated ventricular muscle strips as well as impacts myocardial cells by acting on cell membrane and reduces isometric tension produced by heart.

1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE(6001-64-5)Related Product Information

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