hamaudol
hamaudol Basic information
- Product Name:
- hamaudol
- Synonyms:
-
- hamaudol
- (S)-3,4-Dihydro-3β,5-dihydroxy-2,2,8-trimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
- 2H,6H-Benzo[1,2-b:5,4-b']dipyran-6-one, 3,4-dihydro-3,5-dihydroxy-2,2,8-trimethyl-, (3S)-
- Inhibitor,COX,Hamaudol,Cyclooxygenase,inhibit
- (S)-3,5-Dihydroxy-2,2,8-trimethyl-3,4-dihydro-2H,6H-pyrano[3,2-g]chromen-6-one
- CAS:
- 735-46-6
- MF:
- C15H16O5
- MW:
- 276.28
- Mol File:
- 735-46-6.mol
hamaudol Chemical Properties
- Melting point:
- 197.0-197.5 °C
- Boiling point:
- 464.7±45.0 °C(Predicted)
- Density
- 1.336±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 6.77±0.70(Predicted)
- color
- White to off-white
hamaudol Usage And Synthesis
Uses
Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2].
Definition
ChEBI: Hamaudol is a member of chromenes.
Biological Activity
Hamaudol is a chromone isolated from Saposhnikovia divaricata. It has obvious inhibitory ability on the activities of cyclooxygenase (COX)-1 and COX-2 with IC50 values of 0.30 and 0.57 mM, respectively, and has potent analgesic and anti-inflammatory effects.
in vivo
Hamaudol (Compound 7) increases the potency to exhibit a potent analgesia at doses of 1, 5 and 10 mg/kg in mice, although it do not show clear dose dependency.
< b>
target
| COX-1 < span> 0.3 mM (IC 50 ) | COX-2 0.57 mM (IC 50 ) |
IC 50
COX-1: 0.3 mM (IC50); COX-2: 0.57 mM (IC50)
References
[1] Okuyama E, et al. Analgesic components of saposhnikovia root (Saposhnikovia divaricata). Chem Pharm Bull (Tokyo). 2001 Feb;49(2):154-60. DOI:10.1248/cpb.49.154
[2] Mingshan Zheng, et al. The Constituents Isolated from Peucedanum japonicum Thunb. and their Cyclooxygenase (COX) Inhibitory Activity. Korean Journal of Medicinal Crop Science, 2005, 13(2).
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