Basic information Safety Supplier Related

hamaudol

Basic information Safety Supplier Related

hamaudol Basic information

Product Name:
hamaudol
Synonyms:
  • hamaudol
  • (S)-3,4-Dihydro-3β,5-dihydroxy-2,2,8-trimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
  • 2H,6H-Benzo[1,2-b:5,4-b']dipyran-6-one, 3,4-dihydro-3,5-dihydroxy-2,2,8-trimethyl-, (3S)-
  • Inhibitor,COX,Hamaudol,Cyclooxygenase,inhibit
CAS:
735-46-6
MF:
C15H16O5
MW:
276.28
Mol File:
735-46-6.mol
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hamaudol Chemical Properties

Melting point:
197.0-197.5 °C
Boiling point:
464.7±45.0 °C(Predicted)
Density 
1.336±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
6.77±0.70(Predicted)
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hamaudol Usage And Synthesis

Definition

ChEBI: Hamaudol is a member of chromenes.

Biological Activity

Hamaudol is a chromone isolated from Saposhnikovia divaricata. It has obvious inhibitory ability on the activities of cyclooxygenase (COX)-1 and COX-2 with IC50 values of 0.30 and 0.57 mM, respectively, and has potent analgesic and anti-inflammatory effects.

in vivo

Hamaudol (Compound 7) increases the potency to exhibit a potent analgesia at doses of 1, 5 and 10 mg/kg in mice, although it do not show clear dose dependency.

< b>

target

COX-1

< span> 0.3 mM (IC 50 )

COX-2

0.57 mM (IC 50 )

hamaudolSupplier

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hamaudol(735-46-6)Related Product Information