N-Fmoc-8-Aminooctanoic acid Chemical Properties

Melting point:

118-119 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))

Boiling point:

597.7±33.0 °C(Predicted)

Density 

1.174±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

Powder

pka

4.77±0.10(Predicted)

color 

White

BRN 

8286497

CAS DataBase Reference

126631-93-4(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29242990

MSDS

• Language:English Provider:SigmaAldrich

N-Fmoc-8-Aminooctanoic acid Usage And Synthesis

Description

N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Chemical Properties

White powder

Uses

N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

N-Fmoc-8-Aminooctanoic acid(126631-93-4)Related Product Information

• Fmoc-Phe-OH
• Fmoc-Lys(Boc)-OH
• 1,1'-Carbonyldiimidazole
• Fmoc-Asp(OtBu)-OH
• 8-Aminooctanoic acid
• 6-Aminocaproic acid
• Nalpha-Fmoc-Ndelta-trityl-L-glutamine
• Folic acid
• Glycine
• Octanoic acid
• Hyaluronic acid
• 9-Fluorenylmethyl chloroformate
• CARBONYL SULFIDE
• L-Fmoc-Aspartic acid alpha-tert-butyl ester
• Ethyl 2-(Chlorosulfonyl)acetate
• Citric acid
• Fmoc-OSu
• Ascoric Acid