Aniline hydrochloride Chemical Properties

Melting point:

196-198 °C(lit.)

Boiling point:

245 °C

Density 

1.2215

vapor density 

4.46 (vs air)

refractive index 

1.5330 (estimate)

Flash point:

380 °F

storage temp. 

Store below +30°C.

solubility 

1070g/l

form 

Powder

color 

White to pale yellow-cream

Water Solubility 

1070 g/L (25 ºC)

Sensitive 

Hygroscopic

Merck 

14,659

BRN 

3593823

Stability:

Stable. Incompatible with strong oxidizing agents, strong acids.

CAS DataBase Reference

142-04-1(CAS DataBase Reference)

IARC

2A (Vol. 127)

NIST Chemistry Reference

Benzenamine, hydrochloride(142-04-1)

EPA Substance Registry System

Aniline hydrochloride (142-04-1)

Safety Information

Hazard Codes 

T,N

Risk Statements 

23/24/25-40-41-43-48/23/24/25-50-68

Safety Statements 

26-27-36/37/39-45-61-63-46

RIDADR 

UN 1548 6.1/PG 3

WGK Germany 

2

RTECS 

CY0875000

F 

3-9

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29214100

Toxicity

LD50 orally in Rabbit: 840 mg/kg

MSDS

• Language:English Provider:Aniline hydrochloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Aniline hydrochloride Usage And Synthesis

Description

Aniline (hydrochloride) (Item No. 21963) is an analytical reference standard that is structurally categorized as a synthetic intermediate. It is used to make the imine derivative of NPP as part of the synthesis of fentanyl (Item Nos. 14719 | ISO60197 ) and its derivatives. This product is intended for research and forensic applications.

Chemical Properties

Aniline hydrochloride, a white to greenishcrystalline solid that meltsat 198°C and boils at 245 °C;soluble in water,alcohol, and chloroform; used in making dyes and in printing. Also known as anilinechloride,anilinesalt.

Chemical Properties

Aniline is a clear, colorless, oily liquid that darkens on exposure to light; with a characteristic amine-like odor.

Uses

Intermediates, dyeing and printing, aniline black.

Uses

Aniline hydrochloride was used in the preparation of polyaniline coated poly(styrene-co-styrene sulfonate) nanoparticles. It was used to study the induction of Nei-like DNA glycosylases (NEIL1/2)-mediated base excision repair(BER) in rat spleen and 8-oxoguanine glycosylase 1-mediated BER due to aniline exposure. It is used in printing inks, clothing marking inks, paints and paint removers. It is also used as a stove polisher and shoe polisher, as well as in the synthesis of dyes, crayons and antioxidants.

General Description

A white to greenish colored crystalline solid. Toxic by ingestion and a skin and eye irritant. May emit toxic aniline and chloride fumes under exposure to high temperatures or flame. Used to make dyes and printing ink.

Air & Water Reactions

Aniline hydrochloride is sensitive to air and light (darkens). Soluble in water and denser than water.

Reactivity Profile

Aniline hydrochloride is incompatible with oxidizing materials.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Biochem/physiol Actions

The acute toxicity of aniline involves its activation in vivo to 4-hydroxyaniline and the formation of adducts with hemoglobin. In erythrocytes, this is associated with the release of iron and the accumulation of methemoglobin and the development of hemolytic anemia and inflammation of the spleen. Tumor formation is often observed in the spleen on prolonged administration.

Safety Profile

Suspected carcinogen with experimental carcinogenic and tumorigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental teratogenic effects. Human mutation data reported. A skin and eye irritant. Combustible when exposed to heat or flame. When heated to decomposition or on contact with acid or acid fumes, it emits highly toxic fumes of aniline and chlorine compounds. Reacts explosively with aniline at 240℃/7.6 bar. Can react vigorously with oxidizing materials. To fight fire, use water, CO2, water mist or spray, dry chemical. See also ANILINE.

Potential Exposure

Aniline is widely used as an intermediate in the synthesis of dyestuffs. It is also used in the manufacture of rubber accelerators and antioxidants, pharmaceuticals, marking inks; tetryl, optical whitening agents; photographic developers; resins, varnishes, perfumes, shoe polishes, and many organic chemicals.

Shipping

UN1547 Aniline, Hazard Class: 6.1; Labels: 6.1- Poisonous materials. UN1548 Aniline hydrochloride, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Purification is as for aniline HBr above. [Beilstein 12 IV 232.]

Incompatibilities

May form explosive mixture with air. Unless inhibited (usually methanol), aniline is readily able to polymerize. Fires and explosions may result from contact with halogens, strong acids; oxidizers, strong base organic anhydrides; acetic anhydride, isocyanates, aldehydes, sodium peroxide. Strong reaction with toluene diisocyanate. Reacts with alkali metals and alkali earth metals. Attacks some plastics, rubber and coatings; copper and copper alloys.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration with provision for nitrogen oxides removal from flue gases by scrubber, catalytic or thermal device.

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