3-BROMOISONICOTINIC ACID METHYL ESTER Chemical Properties

Boiling point:

247℃

Density 

1.579

refractive index 

1.56

Flash point:

103℃

storage temp. 

Inert atmosphere,Room Temperature

form 

clear liquid

pka

0.76±0.18(Predicted)

color 

Colorless to Yellow to Orange

CAS DataBase Reference

59786-31-1

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2933399990

3-BROMOISONICOTINIC ACID METHYL ESTER Usage And Synthesis

Uses

Methyl 3-bromoisonicotinate is an important chemical reagent, mainly used as organic synthesis or pharmaceutical intermediates for the preparation of compounds such as alkaloids, tricyclic compounds or small molecule enzyme inhibitors.

Synthesis

3.98 g (20 mmol, 1 eq.) of 3-bromoisonicotinic acid was dissolved in 50 ml of methanol and 4 ml of concentrated sulfuric acid was added as catalyst. The reaction mixture was heated to reflux. After completion of the reaction, it was cooled to room temperature and extracted three times with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. 2.65 g (62% yield) of methyl 3-bromoisonicotinate was obtained. The structure of the product was confirmed by 1H NMR (CDCl3): δ 4.02 (s, 3H), 7.64 (d, J = 4.9 Hz, 1H), 8.63 (d, J = 4.9 Hz, 1H), 8.88 (s, 1H).

References

[1] Patent: US2005/80085, 2005, A1. Location in patent: Page/Page column 12
[2] Patent: US2010/130477, 2010, A1. Location in patent: Page/Page column 58
[3] Patent: US2011/230495, 2011, A1. Location in patent: Page/Page column 23-24
[4] Advanced Synthesis and Catalysis, 2016, vol. 358, # 20, p. 3283 - 3292

3-BROMOISONICOTINIC ACID METHYL ESTER(59786-31-1)Related Product Information

• Bromisoval
• 2-Bromopropane
• Methyl 3-bromopropionate
• Methyl 3-bromobenzoate
• 1-Bromo-2-methylpropane
• Chlorobromoisocyanurate
• 3-Bromoisonicotinic acid
• METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE
• 5-BROMO-2-METHOXY-ISONICOTINIC ACID METHYL ESTER
• 3-BROMOISONICOTINIC ACID METHYL ESTER
• 5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE
• Methyl 5-bromo-2-chloroisonicotinate
• 3-BROMO-4-(METHOXYCARBONYL)-1-METHYLPYRIDINIUM
• SPECS AO-801/41077573
• SPECS AO-801/41077570