2-Fluoro-4-hydroxybenzaldehyde Chemical Properties

Melting point:

168-170°C

Boiling point:

254.2±20.0 °C(Predicted)

Density 

1.350±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

crystalline powder

pka

6.78±0.18(Predicted)

color 

Light tan

InChI

InChI=1S/C7H5FO2/c8-7-3-6(10)2-1-5(7)4-9/h1-4,10H

InChIKey

ONRPXRPUBXXCCM-UHFFFAOYSA-N

SMILES

C(=O)C1=CC=C(O)C=C1F

CAS DataBase Reference

348-27-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22-37/38-41-52

Safety Statements 

26-39

Hazard Note 

Irritant

HS Code 

2912490090

2-Fluoro-4-hydroxybenzaldehyde Usage And Synthesis

Uses

2-Fluoro-4-hydroxybenzaldehyde is a useful reagent for preparation of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors.

Uses

2-Fluoro-4-hydroxybenzaldehyde is mainly used as an intermediate for physiologically active compounds such as pharmaceuticals or pesticides and is a wide range of organic building blocks. Its structure contains fluorine, aldehyde groups, and phenolic hydroxyl groups, and these groups can add or replace other functional groups.

Synthesis

Preparation of 2-fluoro-4-hydroxybenzaldehyde involves: (1) mixing 3-fluorophenol (I), potassium carbonate, and 2-bromopropane in an organic solvent, and heating to react to obtain 1-fluoro-3-isopropoxybenzene (II); (2) dissolving compound (II) in an organic solvent and reacting with a brominating reagent to obtain 1-bromo-2-fluoro-4-isopropoxybenzene (III); (3) dissolving compound (III) in tetrahydrofuran, dripping isopropylmagnesium chloride/tetrahydrofuran solution at -10°C to 0°C, adding dimethylformamide to react after Grignard exchange to obtain 2-fluoro-4-isopropoxybenzaldehyde (IV); and (4) reacting compound (IV) with boron trichloride and deprotecting.

2-Fluoro-4-hydroxybenzaldehyde(348-27-6)Related Product Information

• 4-Hydroxybenzaldehyde
• Benzaldehyde
• Salicylaldehyde
• 3-(Trifluoromethyl)benzaldehyde
• 2-(Trifluoromethyl)benzaldehyde
• 3-Hydroxybenzaldehyde
• 2-Fluoro-4-hydroxybenzoic acid
• 2-Fluoro-4-methylbenzoic acid
• 3-FLUORO-4-HYDROXYBENZALDEHYDE
• Fluorine
• 2-Fluoro-4-methoxyacetophenone
• 2,3,5,6-Tetrafluoro-4-hydroxy-benzoic acid
• 2'-Fluoro-4'-hydroxyacetophenone
• 6-FLUOROVERATRALDEHYDE
• 3-FLUORO-2-HYDROXYBENZALDEHYDE,3-Fluoro-2-Hydroxybenzaldehyde 3-Fluoro Salicylaldehyde,3-Fluoro-2-hydroxybenzaldehyde ,99%
• 2-FLUORO-5-HYDROXYBENZALDEHYDE
• 5-Fluorosalicylaldehyde
• 3,5-Difluoro-4-hydroxybenzaldehyde