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Dithioerythritol

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Dithioerythritol Basic information

Product Name:
Dithioerythritol
Synonyms:
  • (S,R)-DITHIOERYTHRITOL
  • (r*,s*)-1,4-dimercapto-2,3-butanediol
  • 1,4-dimercapto-,(r*,s*)-3-butanediol
  • 1,4-dimercapto-,(theta,s)-3-butanediol
  • 1,4-dithio-erythrito
  • DITHIOERYTHRITOL MOLECULAR BIOLOGY*REAGE NT
  • DITHIOERYTHRITOL, 99+%
  • DITHIOERYTHRITOL SIGMAULTRA
CAS:
6892-68-8
MF:
C4H10O2S2
MW:
154.25
EINECS:
229-998-8
Product Categories:
  • Pharmaceutical Intermediates
  • Antioxidant
  • Biochemistry
  • Erythrose
  • O-Substituted Sugars
  • Sugar Alcohols
  • Sugars
  • proteinmod
Mol File:
6892-68-8.mol
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Dithioerythritol Chemical Properties

Melting point:
82-84 °C(lit.)
Boiling point:
247.65°C (rough estimate)
Density 
1.156 (estimate)
refractive index 
1.5200 (estimate)
storage temp. 
2-8°C
solubility 
H2O: 10 mg/mL, clear, colorless
form 
Powder
pka
pK1:9.5 (25°C)
color 
White to pale yellow or beige
PH
4.0-6.0 (25℃, 0.1M in H2O)
Water Solubility 
Soluble
Sensitive 
Air Sensitive
λmax
λ: 260 nm Amax: 0.400
λ: 280 nm Amax: 0.050
BRN 
1719756
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
VHJLVAABSRFDPM-ZXZARUISSA-N
CAS DataBase Reference
6892-68-8(CAS DataBase Reference)
EPA Substance Registry System
1,4-Dithioerythritol (6892-68-8)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36-37/39
RIDADR 
UN 3335
WGK Germany 
3
RTECS 
KF2410000
3-10-13-23
TSCA 
Yes
HazardClass 
9
HS Code 
29309070

MSDS

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Dithioerythritol Usage And Synthesis

Chemical Properties

White solid

Uses

Reagent for the reduction of disulfide group. Prevents oxidation of sulfhydryl-containing proteins during SDS-polyacrylamide gel electrophoresis. Cleavage of disulfide bonds in proteins

Uses

1,4-Dithioerythritol is a Michael reaction acceptor; inducers of enzymes that protect against carcinogenesis: reactivity with sulfhydryl groups.

Uses

Reagent for maintaining ?SH groups in the reduced state; quantitatively reduces disulfides.

Definition

ChEBI: The meso-diastereomer of 1,4-dimercaptobutane-2,3-diol; a sulfur-containing sugar derived from the monosaccharide erythrose; and an epimer of dithiothreitol.

Purification Methods

Crystallise DTE from ether/hexane and store it in the dark at 0o. [Beilstein 1 III 2360.]

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