[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID Chemical Properties

Melting point:

116 - 118°C

Boiling point:

602.1±55.0 °C(Predicted)

Density 

1.160

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

pka

3.51±0.10(Predicted)

form 

Solid

color 

Off-White to Light Yellow

[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID Usage And Synthesis

Description

Prostacyclin (PGI₂) is a potent vasorelaxant and inhibitor of platelet aggregation. It mediates its actions by binding to a specific G protein-coupled receptor, the IP receptor, on the surface of endothelial cells, arterial smooth muscle, and platelets. The IP receptor also participates in signal transduction of the pain response, cardioprotection, and inflammation. MRE-269 is the active form of the prodrug NS-304. It is a potent and selective agonist for the human IP receptor with a K_i value of 20 nM. In contrast to PGI₂, which has a half-life of 30 seconds to a few minutes in vivo, plasma concentrations of MRE-269 remain near peak levels for more than eight hours in rats and dogs. Unlike the PGI₂ analogues, beraprost and iloprost, MRE-269 lacks high affinity for the EP₃ receptor. As a result, MRE-269 induces vasodilation equally in large and small pulmonary arteries, whereas vasodilation of small arteries by beraprost and iloprost is reduced via EP₃-mediated vasoconstriction.

Uses

MRE-269 an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269 is used for the treatment of pulmonary arterial hypertension. MRE-269 is an active metabolite of Selexipag (S253150).

Definition

ChEBI: A member of the class of pyrazines that is {4-[(propan-2-yl)(pyrazin-2-yl)amino]butoxy}acetic acid carrying two additional phenyl substituents at positions 5 and 6 on the pyrazine ring. The active metabolite of selexipag, an orphan drug used for the treatm nt of pulmonary arterial hypertension.

[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID(475085-57-5)Related Product Information

• 5-chloro-2,3-diphenylpyrazine
• ( 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid tert-butylester )
• SELEXIPAG interMediate
• 2,3-DIPHENYLPYRAZINE
• Bromoacetic acid
• 2-T-BUTYL GLYCOLATE
• 4-(Isopropylamino)butanol
• 5,6-DIPHENYLPYRAZIN-2-OL
• N-(methylsulfonyl)glycine
• 2,3-Dichloro-5,6-diphenylpyrazine
• Pyrazinamide
• Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide
• Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)oxy]butoxy]-
• 2-Pyrazinamine, N-(1-methylethyl)-5,6-diphenyl-
• 1-Butanol, 4-[(5,6-diphenyl-2-pyrazinyl)oxy]-
• Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)oxy]butoxy]-, 1,1-dimethylethyl ester
• Acetamide, 2-[4-[(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)-
• Acetamide, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-