4-(Isopropylamino)butanol Chemical Properties

Boiling point:

85°C/1mmHg(lit.)

Density 

0.889 g/cm3

refractive index 

1.4480-1.4520

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

clear liquid

pka

15.13±0.10(Predicted)

color 

Colorless to Almost colorless

InChI

InChI=1S/C7H17NO/c1-7(2)8-5-3-4-6-9/h7-9H,3-6H2,1-2H3

InChIKey

IPLWOCGPIGUXOR-UHFFFAOYSA-N

SMILES

C(O)CCCNC(C)C

Safety Information

RIDADR 

1993

HazardClass 

3

PackingGroup 

III

HS Code 

2922190090

4-(Isopropylamino)butanol Usage And Synthesis

Chemical Properties

4-(Isopropylamino)butanol is a colorless liquid with an alkaline reaction. It reacts easily with acids and is soluble in water. The boiling point of this substance is 242°C. In the presence of ammonium chloride, the solution becomes acidic.

Uses

4-(Isopropylamino)butanol is used as a solvent for paints, varnishes, and lacquers.

Synthesis

The general procedure for the synthesis of 4-(isopropylamino)butanol from 4-amino-1-butanol and acetone was as follows: 200 g of 4-amino-1-butanol (II) was dissolved in a solvent mixture of 400 ml of acetone and 1,000 ml of ethanol, to which was added 20 g of 10% Pd/C catalyst. The hydrogenation reaction was carried out at a hydrogen pressure of 10 atmospheres for 4 to 5 hours. Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst and the filtrate was subsequently concentrated to afford the target compound 4-(isopropylamino)butanol as a colorless oil in quantitative yield.

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7128 - 7137
[2] Patent: WO2017/60827, 2017, A1. Location in patent: Page/Page column 11
[3] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 21, p. 6692 - 6704
[4] Patent: EP1400518, 2004, A1. Location in patent: Page 21

4-(Isopropylamino)butanol(42042-71-7)Related Product Information

• 4,4-DIMETHYL-2-PENTANOL
• Tropine
• 5-chloro-2,3-diphenylpyrazine
• ( 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid tert-butylester )
• SELEXIPAG interMediate
• [4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID
• 2,3-DIPHENYLPYRAZINE
• Bromoacetic acid
• 2-T-BUTYL GLYCOLATE
• 5,6-DIPHENYLPYRAZIN-2-OL
• N-(methylsulfonyl)glycine
• 2,3-Dichloro-5,6-diphenylpyrazine
• Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)oxy]butoxy]-
• 2-Pyrazinamine, N-(1-methylethyl)-5,6-diphenyl-
• 1-Butanol, 4-[(5,6-diphenyl-2-pyrazinyl)oxy]-
• Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)oxy]butoxy]-, 1,1-dimethylethyl ester
• Acetamide, 2-[4-[(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)-
• Acetamide, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-