ChemicalBook > Product Catalog > Biochemical Engineering > Amino Acids and Derivatives > Proline derivatives > (4S)-4-hydroxy-L-proline hydrochloride
(4S)-4-hydroxy-L-proline hydrochloride
(4S)-4-hydroxy-L-proline hydrochloride Basic information
- Product Name:
- (4S)-4-hydroxy-L-proline hydrochloride
- Synonyms:
-
- (4S)-4-hydroxy-L-proline hydrochloride
- L-Proline, 4-hydroxy-,hydrochloride, cis-
- L-Proline,4-hydroxy-,hydrochloride(1:1),(4S)-
- H-cis-Hyp-OH·HCl
- cis-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride
- L-Proline, 4-hydroxy-, hydrochloride, (4S)-
- (2s,4S)-4-hydroxy-L-proline hydrochloride
- Cis-4-hydroxy-L-prolineMonohydrochloride
- CAS:
- 441067-49-8
- MF:
- C5H10ClNO3
- MW:
- 167.5908
- EINECS:
- 1592732-453-0
- Mol File:
- 441067-49-8.mol
More
Less
(4S)-4-hydroxy-L-proline hydrochloride Chemical Properties
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Solid
- color
- White to light yellow
- optical activity
- -12.74°(C=1.01g/100mI, MEOH, 20°C, 589nm)
More
Less
(4S)-4-hydroxy-L-proline hydrochloride Usage And Synthesis
Uses
cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
IC 50
Non-cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
(4S)-4-hydroxy-L-proline hydrochlorideSupplier
Meryer (Shanghai) Chemical Technology Co., Ltd.
- Tel
- 4006356688 18621169109
- market03@meryer.com
Beijing Ouhe Technology Co., Ltd
- Tel
- 010-010-82967028 13522913783
- 2355560935@qq.com
Pure Chemistry Scientific Inc.
- Tel
- 001-857-928-2050 or 1-888-588-9418
- sales@chemreagents.com
Adamas Reagent, Ltd.
- Tel
- 400-6009262 16621234537
- chenyj@titansci.com
Shanghai Boc Chemical Co.,Ltd
- Tel
- 021-34975603-808 18721111801
- sales@bocpharma.com
More
Less
(4S)-4-hydroxy-L-proline hydrochloride(441067-49-8)Related Product Information
- L-Phenylalanine
- Methyl cis-4-Aminocyclohexanecarboxylate Hydrochloride
- Cis-4-Aminoadamantan-1-ol hydrochloride
- cis-4-Aminocyclohexanecarboxylic acid
- 4α-Aminocyclohexan-1α-ol
- CIS-4-CYCLOHEXENE-1,2-DICARBOXYLIC ACID
- CIS-4-METHYL-CYCLOHEXYLAMINE HCL
- 4-aminocyclohexan-1-ol
- cis-4-Hydroxy-D-proline
- L-Lysine
- L-Cysteine
- cis-4-Hydroxy-L-proline
- cis-4-Hydroxy-D-proline hydrochloride