Methyl 2,3-dichloropropionate Chemical Properties

Boiling point:

52-55 °C/2 mmHg (lit.)

Density 

1.325 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.453(lit.)

Flash point:

145 °F

storage temp. 

Store below +30°C.

solubility 

Soluble in ether, acetone, ethanol.

color 

Colorless to Almost colorless

BRN 

1701891

InChI

InChI=1S/C4H6Cl2O2/c1-8-4(7)3(6)2-5/h3H,2H2,1H3

InChIKey

OFHMODDLBXETIK-UHFFFAOYSA-N

SMILES

C(OC)(=O)C(Cl)CCl

CAS DataBase Reference

3674-09-7(CAS DataBase Reference)

NIST Chemistry Reference

Propanoic acid, 2,3-dichloro-, methyl ester(3674-09-7)

EPA Substance Registry System

Propanoic acid, 2,3-dichloro-, methyl ester (3674-09-7)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-10

Safety Statements 

23-24/25-37/39-26-16

RIDADR 

1993

WGK Germany 

3

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29159000

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Methyl 2,3-dichloropropionate Usage And Synthesis

Chemical Properties

clear colorless to slightly yellow liquid

Uses

Methyl 2,3-dichloropropionate can be used to produce 2-chloro-acrylic acid methyl ester at Heating. It is used as pharmaceutical intermediate.

Application

Methyl 2,3-Dichloropropanoate is a useful reagent in preparation of oxidative fragmentation and coupling of catharanthine analogs to vindoline.

Synthesis

Preparation of Methyl 2,3-dichloropropanoate:
Methyl acrylate (2366 g, 27.5 mol) and dimethylformamide (DMF) (40 g, 0.55 mol) was placed in a 3-liter three necked flask fitted with a stirrer, thermometer, inlet tube and gas trap. Chlorine (950 g, 0.48 mol) was passed into the methyl acrylate rapidly over a period of ten hours while the temperature was kept below 40°C. Reaction progress was monitored by gas chromatography (GC). When it seemed that 50 percent of chlorine was consumed, the reaction was stopped. The reaction mass was taken for distillation to separate methylacrylate and Methyl 2,3-dichloropropanoate. The contents were subjected to vacuum distillation. Methyl 2,3-dichloropropanoate was collected distilling at 70°C with 15mm.Yield (%):77.2, Purity (%) = 98.

Methyl 2,3-dichloropropionate(3674-09-7)Related Product Information

• Methyl propionate
• Methyl acrylate
• Acetonitrile
• Kresoxim-methyl
• Methyl 2-bromopropionate
• Paraquat dichloride
• Quinclorac
• Thionyl chloride
• Methyl levulinate
• 1,2-Dichloroethane
• Methylparaben
• N,N-Dimethylacetamide
• Basic Violet 1
• Methyl 2-chloropropionate
• Methyl 3-bromopropionate
• Methanol
• Methyl acetate
• Dichloroethane