BenzaMide, N-[4-chloro-3-(trifluoroMethyl)phenyl]-2-[2-(diMethylaMino)ethoxy]-6-ethoxy- CAS#: 1311423-89-8

BenzaMide, N-[4-chloro-3-(trifluoroMethyl)phenyl]-2-[2-(diMethylaMino)ethoxy]-6-ethoxy- Basic information

Product Name:

BenzaMide, N-[4-chloro-3-(trifluoroMethyl)phenyl]-2-[2-(diMethylaMino)ethoxy]-6-ethoxy-

Synonyms:

BenzaMide, N-[4-chloro-3-(trifluoroMethyl)phenyl]-2-[2-(diMethylaMino)ethoxy]-6-ethoxy-
N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy]-6-ethoxybenzamide
YF-2;YF 2
YF 2,HATs,inhibit,HAT,Histone Acetyltransferase,Inhibitor,YF2,YF-2
YF-2, 10 mM in DMSO

CAS:

1311423-89-8

MF:

C20H22ClF3N2O3

MW:

430.85

Product Categories:

API

Mol File:

1311423-89-8.mol

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BenzaMide, N-[4-chloro-3-(trifluoroMethyl)phenyl]-2-[2-(diMethylaMino)ethoxy]-6-ethoxy- Chemical Properties

Boiling point:: 460.8±45.0 °C(Predicted)
Density: 1.285±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
form: A crystalline solid
pka: 11.75±0.70(Predicted)
color: Light yellow to yellow

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BenzaMide, N-[4-chloro-3-(trifluoroMethyl)phenyl]-2-[2-(diMethylaMino)ethoxy]-6-ethoxy- Usage And Synthesis

Uses

YF-2 is an activator of histone acetyltransferase (HAT).

in vivo

YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice^[1].

IC 50

GCN5/PCAF: 29.04 μM (EC₅₀); GCN5: 49.31 μM (EC₅₀); CBP: 2.75 μM (EC₅₀)

BenzaMide, N-[4-chloro-3-(trifluoroMethyl)phenyl]-2-[2-(diMethylaMino)ethoxy]-6-ethoxy-Supplier

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