Yhhu-3792 Chemical Properties

Boiling point:

608.8±65.0 °C(Predicted)

Density 

1.239±0.06 g/cm3(Predicted)

pka

7.81±0.30(Predicted)

form 

Solid

color 

Light yellow to yellow

Yhhu-3792 Usage And Synthesis

Uses

Yhhu-3792 enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) in mouse. Yhhu-3792 increases the spatial and episodic memory abilities of mice. Yhhu-3792 has the potential for the research of impairment of learning and memory associated DG dysfunction[1].

References

[1] Lu H, et al. A Novel 2-Phenylamino-Quinazoline-Based Compound Expands the Neural Stem Cell Pool and Promotes the Hippocampal Neurogenesis and the Cognitive Ability of Adult Mice. Stem Cells. 2018 Aug;36(8):1273-1285. DOI:10.1002/stem.2843

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