YS 49
YS 49 Basic information
- Product Name:
- YS 49
- Synonyms:
-
- YS 49
- 1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate
- 1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide
- CS-884
- YS 49;YS49
- inhibit,YS-49,PI3K,Adrenergic Receptor,Phosphoinositide 3-kinase,PKB,Beta Receptor,YS 49,Akt,Protein kinase B,Inhibitor,YS49,Angiotensin Receptor
- CAS:
- 132836-42-1
- MF:
- C20H20BrNO2
- MW:
- 386.2823
- Product Categories:
-
- Akt
- mTOR
- PI3K/Akt/mTOR
- PI3K
- Mol File:
- 132836-42-1.mol
YS 49 Chemical Properties
- storage temp.
- 2-8°C
- solubility
- H2O: >10mg/mL
- form
- solid
YS 49 Usage And Synthesis
Biological Activity
YS-49 is an activator of PI3K/Akt, a downstream target of RhoA, and reduces RhoA/PTEN activation in 3-methylcholine-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated VSMC proliferation by inducing heme oxygenase (HO-1). YS-49 is an isoquinoline compound alkaloid with strong positive inotropic effects due to its ability to activate cardiac β-adrenoceptors.
in vitro
YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC 50 values of 22 μM and 30 μM, respectively.
YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.
Cell Viability Assay
| Cell Line: | RAVSMC and RAW 264.7 cells |
| Concentration: | 10 μM, 30 μM and 100 μM (RAVSMC cells); 1 μM, 10 μM and 100 μM (RAW 264.7 cells) |
| Incubation Time: | 18 hours |
| Result: | Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC 50 values of 22 and 30 μM, respectively . |
Western Blot Analysis
| Cell Line: | RAVSMC and RAW 264.7 cells |
| Concentration: | 10 μΜ, 30 μΜ and 100 μΜ |
| Incubation Time: | 18 hours |
| Result: | Concentration -dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ. |
in vivo
YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM. < /p>
| Animal Model: | Male Sprague Dawley rats (250-300 g) |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; 8 hours |
| Result: | Serum NOx levels were significantly reduced. |
YS 49Supplier
- Tel
- sales@boylechem.com
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- 021-58950125
- info@chemexpress.com
- Tel
- 021-58955995
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- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
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- 0086-571-86217390
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