4-[(AMinocarbonyl)aMino]-N-[(9H-fluoren-9-ylMethoxy)carbonyl]-D-phenylalanine Chemical Properties

Melting point:

163℃ (decomposition)

Boiling point:

699.1±55.0 °C(Predicted)

Density 

1.376±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)

pka

3.82±0.10(Predicted)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

InChIKey

HFPDOFBZCSQAEJ-JOCHJYFZSA-N

SMILES

C(O)(=O)[C@@H](CC1=CC=C(NC(N)=O)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

4-[(AMinocarbonyl)aMino]-N-[(9H-fluoren-9-ylMethoxy)carbonyl]-D-phenylalanine Usage And Synthesis

Uses

Fmoc-D-4-Aph(cBm)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize biologically active peptide mimetics, such as Ac-D2Nal-D4Cpa-D3Pal-Ser-4Aph/4Amf(P)-D4Aph/D4Amf(Q)-Leu-ILys-Pro-DAla-NH2 with gonadotropin-releasing hormone (GnRH) antagonist activity[1].

References

[1] Guangcheng Jiang, et al. "GnRH antagonists: a new generation of long acting analogues incorporating p-ureido-phenylalanines at positions 5 and 6." Journal of medicinal chemistry 44.3 (2001): 453-467. DOI:10.1021/jm0003900

4-[(AMinocarbonyl)aMino]-N-[(9H-fluoren-9-ylMethoxy)carbonyl]-D-phenylalanine(324017-22-3)Related Product Information

• FMoc-D-4-Aph(tBu-CbM)-OH
• Fmoc-3-(2-Naphthyl)-D-alanine
• Fmoc-N-Me-Tyr(tBu)-OH
• FMOC-D-CIT-OH
• FMOC-D-alanine
• (9H-Fluoren-9-yl)MethOxy]Carbonyl HomoArg(Et)2-OH·HCl (symmetrical)
• FMOC-D-4-Chlorophe
• FMOC-LYS(BOC)(ISOPROPYL)-OH
• Fmoc-Lys(nicotinoyl)-OH
• (R)-N-Acetyl-2-naphthylalanine
• Fmoc-D-Asn(Trt)-OH
• Fmoc-D-homoArg(Et)2-OH·HCl
• Fmoc-Lys(Pal-Glu-OtBu)-OH
• (R)-N-Fmoc-(3-Pyridyl)alanine
• N-[(9H-Fluoren-9-ylMethoxy)carbonyl]-4-[[[(4S)-hexahydro-2,6-dioxo-4-pyriMidinyl]carbonyl]aMino]-L-phenylalanine