3-Hydroxy-4-methoxybenzyl alcohol Chemical Properties

Melting point:

135-137 °C (lit.)

Boiling point:

315.8±27.0 °C(Predicted)

Density 

1.226±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

9.75±0.10(Predicted)

color 

White to Almost white

BRN 

1867860

CAS DataBase Reference

4383-06-6(CAS DataBase Reference)

NIST Chemistry Reference

3-Hydroxy-4-methoxybenzyl alcohol(4383-06-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25-36-26

WGK Germany 

3

HS Code 

29094990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-Hydroxy-4-methoxybenzyl alcohol Usage And Synthesis

Chemical Properties

White crystalline

Uses

3-Hydroxy-4-methoxybenzyl alcohol was used in preparation of 2-hydroxymethyl-5-methoxy-2,5-cyclohexadiene-1,4-dione by oxidation with Fremy′s salt.

Synthesis

3-Hydroxy-4-methoxybenzyl alcohol is synthesised using isovanillin as raw material by chemical reaction. The specific synthesis steps are as follows:
In a round-bottom flask equipped with magnetic stirrer was added 15 sodium borohydride (0.2mmol; 0.01g) to the solution of 9 1 (0.2mmol; 0.03g) prepared in ethanol (1mL). The mixture was stirred at room temperature for 30min. The consumption of all starting material was detected by thin layer chromatography (TLC); the solvent was evaporated under reduced pressure. Subsequently, 10mL of saturated NaCl solution was added and then extracted with ethyl acetate (3×10mL). The organic phase was dried over anhydrous MgSO4, filtered and evaporated, providing 0.03g of colorless oil, 90% yield of 3-Hydroxy-4-methoxybenzyl alcohol.

3-Hydroxy-4-methoxybenzyl alcohol(4383-06-6)Related Product Information

• Triphenylmethanol
• Benzhydrol
• CHLOROPHOSPHONAZO III
• m-Anisyl alcohol
• 4-Hydroxybenzyl alcohol
• 3,4-Dimethoxybenzyl alcohol
• Ethyl acetate
• Benzyl alcohol
• 3,5-Dimethoxybenzyl alcohol
• 3,4-Dimethoxybenzoic acid
• 2,3,4-Trimethoxybenzoic acid
• Reserpine
• 3,4,5-Trimethoxy benzoic acid
• 3,4-Diethoxybenzoic acid
• 3-Hydroxy-4,5-dimethoxybenzoic acid
• (+)-Bicuculline
• 3-Hydroxy-4-methoxybenzoic acid
• DL-4-HYDROXY-3-METHOXYMANDELIC ACID