ML 154
ML 154 Basic information
- Product Name:
- ML 154
- Synonyms:
-
- ML 154
- 3-(Diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]imidazo[1,2-a]pyridinium bromide
- NCGC 84 (ML154)
- ML 154,inhibit,Inhibitor,ML-154,NCGC-84,NCGC84,addiction,food disorder,NCGC 84,NPSR,anxiety,ML154
- CAS:
- 1345964-89-7
- MF:
- C29H26BrN2PS
- MW:
- 545.48
- Mol File:
- 1345964-89-7.mol
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ML 154 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO: 10 mg/ml, sonicated
- form
- A solid
- color
- White to off-white
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ML 154 Usage And Synthesis
Uses
ML 154 is a potent neuropeptide S receptor antagonist which may be used in the treatment of sleep, anxiety and addiction disorders.
in vivo
ML154 (NCGC84; 1 mg/kg; i.p; once) blocks alcohol-induced ERK-phosphorylation in the rat central amygdala, a region involved in regulation of alcohol intake. ML154 also decreases operant alcohol self-administration, and lowers motivation for alcohol reward as measured using progressive ratio responding[1].
| Animal Model: | Male Wistar rats (300-350 g) injected with alcohol[1] |
| Dosage: | 1 mg/kg (10% Solutol, 10% N,N-dimethylacetamide, and 80% 10 mM PBS, pH 7.4) |
| Administration: | Intraperitoneal injection; once |
| Result: | Inhibited alcohol-induced central ERK phosphorylation in vivo. |
storage
Store at +4°C
ML 154Supplier
Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
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Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
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InvivoChem
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- +1-708-310-1919 +1-13798911105
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BOC Sciences
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